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US4469792A
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Blood gas calibration and control fluid utilizing stroma-free hemoglobin
Assignee: IL Holding Spa
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Filing: 1981-08-05
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Granted: 1984-09-04
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Expires: 2001-08-05
Abstract
Abstract A reference fluid for the calibration and control of blood gas instruments is comprised of substantially pure stroma-free hemoglobin solution, a buffering agent, a source of bicarbonate ion and predetermined amounts of gases found in in vivo blood.
Inventors
- 👤 Richard S. Simmonds
- 👤 Wells P. Owen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:26
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/795; C07K14/805; A; A61; A61K; A61K38/00; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/105831; Y10T436/106664; Y10T436/107497
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
27 words
A stable reference fluid comprising substantially pure stroma-free hemoglobin solution, a source of bicarbonate ion, a buffer and predetermined amounts of gases present in in vivo blood.
Claim 2
Dependent Claim
27 words
A stable reference fluid comprising substantially pure stroma-free hemoglobin solution, a source of bicarbonate ion, a buffer and predetermined amounts of gases present in in vivo blood.
Claim 3
Dependent Claim
16 words
The reference fluid of claim 1 in which the source of bicarbonate ion is sodium carbonate.
Claim 4
Dependent Claim
22 words
The reference fluid of claim 2 wherein said sodium carbonate is present at a level of up to 75 millimoles/liter of solution.
Claim 5
Dependent Claim
8 words
The reference fluid of claim 1 containing oxygen.
Claim 6
Dependent Claim
25 words
The reference fluid of claim 4 wherein the partial pressure of oxygen (P O .sbsb.2) is between 10 and 500 mm. Hg at 37° C.
Claim 7
Dependent Claim
10 words
The reference fluid of claim 1 containing CO 2 .
Claim 8
Dependent Claim
26 words
The reference fluid of claim 6 wherein the partial pressure of carbon dioxide (P CO .sbsb.2) is between 5 and 100 mm. Hg at 37° C.
Claim 9
Dependent Claim
9 words
The reference fluid of claim 1 containing an electrolyte.
Claim 10
Dependent Claim
13 words
The reference fluid of claim 1 having a pH of 6.8 to 8.0.
Claim 11
Dependent Claim
14 words
The reference fluid of claim 1 packaged in a sealed ampule impermeable to air.
Claim 12
Dependent Claim
37 words
A stable reference fluid for use in calibration and control of blood gas instruments which comprises substantially pure stroma-free hemoglobin, a source of bicarbonate ion, a buffer, and electrolyte, and predetermined amounts of oxygen and carbon dioxide.
Claim 13
Dependent Claim
37 words
A stable reference fluid for use in calibration and control of blood gas instruments which comprises substantially pure stroma-free hemoglobin, a source of bicarbonate ion, a buffer, and electrolyte, and predetermined amounts of oxygen and carbon dioxide.
Claim 14
Dependent Claim
91 words
A stable reference fluid for use in calibration and control of blood gas instruments which comprises a substantially pure stroma-free hemoglobin solution containing 6 to 18 percent hemoglobin, up to 75 millimoles/liter of solution of sodium carbonate, a buffer, an electrolyte, oxygen in an amount sufficient to provide a partial pressure of 10 to 500 mm. Hg at 37° C., and carbon dioxide in an amount sufficient to provide a partial pressure of 5 to 100 mm. Hg at 37° C., the pH of the fluid being between 6.8 and 8.0.
Claim 15
Dependent Claim
91 words
A stable reference fluid for use in calibration and control of blood gas instruments which comprises a substantially pure stroma-free hemoglobin solution containing 6 to 18 percent hemoglobin, up to 75 millimoles/liter of solution of sodium carbonate, a buffer, an electrolyte, oxygen in an amount sufficient to provide a partial pressure of 10 to 500 mm. Hg at 37° C., and carbon dioxide in an amount sufficient to provide a partial pressure of 5 to 100 mm. Hg at 37° C., the pH of the fluid being between 6.8 and 8.0.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-04 | 1988-03-05 | 1988-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-04 | 1992-03-05 | 1992-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-04 | 1996-03-05 | 1996-09-04 | $7700.00 | Window Closed / Lapsed |