Quino-benzothiazine antibacterial compounds

Claim 1

A compound having the formula ##STR43## wherein R 1 is hydrogen or a carboxy protecting group; R 2 is one or more groups selected from the group consisting of hydrogen, halogen, nitro, carboxyl, methylenedioxy, cyano, C 1 to C 6 alkyl halo-substituted C 1 to C 6 alkyl, hydroxy-substituted C 1 to C 6 alkyl, a group having the formula: --Y--R.sub.3 wherein --Y-- is --O-- or --S-- and R 3 is hydrogen or C 1 to C 6 alkyl, and an amine group having the formula: ##STR44## wherein R 4 and R 5 are independently hydrogen or C 1 to C 6 alkyl; and Z is selected from the group consisting of an aliphatic heterocyclic ring having the structure ##STR45## wherein R 8 is methylene, dimethylene or a group of the formula --CH 2 --CH 2 --R 9 --CH 2 or --CH 2 --R 9 --CH 2 -- wherein R 9 is selected from the group consisting of --S--, --O-- and --N--; substituted derivatives thereof having one or more substitutents selected from the group consisting of C 1 to C 6 alkyl, C 1 to C 6 hydroxyalkyl, hydroxy, alkanoyl contaning 1 to 6 carbon atoms, alkanoylamido containing 1 to 6 carbon atoms and an amine of the formula ##STR46## wherein R 10 and R 11 are each independently selected from the group consisting of hydrogen, C 1 to C 6 alkyl, halo-substituted C 1 to C 6 alkyl and hydroxy-substituted C 1 to C 6 alkyl; and an amino group of the formula ##STR47## wherein R 6 is hydrogen or C 1 to C 10 alkyl, halo-substituted C 1 to C 10 alkyl or hydroxy-substituted C 1 to C 10 alkyl; and R 7 is selected from the group consisting of C 1 to C 10 alkyl, halo-substituted C 1 to C 10 alkyl, hydroxy-substituted C 1 to C 10 alkyl, an amine group, a mono-(C 1 to C 6 )alkylamino group and a di-(C 1 to C 6 )alkylamino group, and pharmaceutically acceptable salts thereof.