Patent US4590183A successfully refreshed from Google Patents.
US4590183A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Gastric cytoprotection with sodium thiosulfate in oral administration of aspirin
Assignee: STWB Inc
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Filing: 1985-04-22
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Granted: 1986-05-20
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Expires: 2005-04-22
Abstract
Abstract The method of providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate alone or in combination with a pharmaceutically acceptable carrier. Also shown is a composition for providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises aspirin in combination with a cytoprotectively effective amount of sodium thiosulfate.
Inventors
- 👤 Denis M. Bailey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 08:06
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/04; A61P; A61P1/00; A61P1/04; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
49 words
The method of providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate, using at least about 0.15 part of sodium thiosulfate per part by weight of aspirin.
Claim 2
Independent Claim
49 words
The method of providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate, using at least about 0.15 part of sodium thiosulfate per part by weight of aspirin.
Claim 3
Dependent Claim
21 words
The method according to claim 1 wherein the aspirin and sodium thiosulfate are administered in combination with a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim
17 words
The method according to claim 1 wherein aspirin and sodium thiosulfate are administered in combination dosage form.
Claim 5
Dependent Claim
30 words
The method according to claim 1 wherein about 0.5 to 1.5 parts by weight of sodium thiosulfate and 1 part by weight of aspirin are administered in combination dosage form.
Claim 6
Dependent Claim
23 words
The method according to claim 1 wherein about equal parts by weight of sodium thiosulfate and aspirin are administered in combination dosage form.
Claim 7
Dependent Claim
17 words
The method according to claim 1 wherein aspirin and sodium thiosulfate are administered in separate dosage form.
Claim 8
Independent Claim
48 words
The method of preventing or inhibiting gastric lesions in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate, using at least about 0.15 part of sodium thiosulfate per part by weight of aspirin.
Claim 9
Independent Claim
48 words
The method of preventing or inhibiting gastric lesions in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate, using at least about 0.15 part of sodium thiosulfate per part by weight of aspirin.
Claim 10
Dependent Claim
21 words
The method according to claim 7 wherein the aspirin and sodium thiosulfate are administered in combination with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
17 words
The method according to claim 7 wherein aspirin and sodium thiosulfate are administered in combination dosage form.
Claim 12
Dependent Claim
30 words
The method according to claim 7 wherein about 0.5 to 1.5 parts by weight of sodium thiosulfate and 1 part by weight of aspirin are administered in combination dosage form.
Claim 13
Dependent Claim
23 words
The method according to claim 7 wherein about equal parts by weight of sodium thiosulfate and aspirin are administered in combination dosage form.
Claim 14
Dependent Claim
17 words
The method according to claim 7 wherein aspirin and sodium thiosulfate are administered in separate dosage form.
Claim 15
Dependent Claim
43 words
A composition for providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises aspirin in combination with a cytoprotectively effective amount of sodium thiosulfate, using at least about 0.15 part of sodium thiosulfate per part by weight of aspirin.
Claim 16
Dependent Claim
43 words
A composition for providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises aspirin in combination with a cytoprotectively effective amount of sodium thiosulfate, using at least about 0.15 part of sodium thiosulfate per part by weight of aspirin.
Claim 17
Dependent Claim
18 words
A composition according to claim 13 comprising aspirin and sodium thiosulfate in combination with a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
17 words
A composition according to claim 13 wherein the aspirin and sodium thiosulfate are isolated from each other.
Claim 19
Dependent Claim
22 words
A composition according to claim 13 in unit dosage form comprising a mixture of aspirin and sodium thiosulfate in a gelatin capsule.
Claim 20
Dependent Claim
29 words
A composition according to claim 13 in unit dosage form comprising a mixture of aspirin and sodium thiosulfate in combination with a pharmaceutically acceptable excipient in a gelatin capsule.
Claim 21
Dependent Claim
21 words
A composition according to claim 13 comprising about 0.15 to 3 parts by weight of sodium thiosulfate per part of aspirin.
Claim 22
Dependent Claim
21 words
A composition according to claim 13 comprising about 0.5 to 1.5 parts by weight of sodium thiosulfate per part of aspirin.
Claim 23
Dependent Claim
17 words
A composition according to claim 13 comprising about equal parts by weight of sodium thiosulfate and aspirin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-19 | 1989-11-18 | 1990-05-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-19 | 1993-11-18 | 1994-05-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-19 | 1997-11-18 | 1998-05-20 | $7700.00 | Window Closed / Lapsed |