US4661349A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Herpes simplex virus subunit vaccine
Assignee: Chemo Sero Therapeutic Research Institute Kaketsuken
•
Filing: 1986-07-09
•
Granted: 1987-04-28
•
Expires: 2006-07-09
Abstract
Abstract An improved herpes simplex virus subunit vaccine being effective against both of HSV type 1 and type 2 and having high safety and high effectiveness, which comprises as an active component a highly purified glycoprotein gB which is a component common to Herpes simplex virus type 1 and type 2, and a method for preparing the herpes simplex virus subunit vaccine and also a lyophilized preparation of the vaccine.
Inventors
- 👤 Yoichiro Kino
- 👤 Nobuya Ohtomo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:22
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/245; C; C07; C07K; C07K14/00; C07K14/005; C12; C12N; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16622
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
54 words
A method for preparing a herpes simplex subunit vaccine, which comprises subjecting a solution containing herpes simplex virus glycoproteins to affinity chromatography using as a ligand a monoclonal antibody against herps simplex virus glycoprotein gB, and adsorbing the resulting purified glycoprotein gB onto an aluminum gel to obtain a glycoprotein gB-adsorbed aluminum gel dispersion.
Claim 2
Independent Claim
54 words
A method for preparing a herpes simplex subunit vaccine, which comprises subjecting a solution containing herpes simplex virus glycoproteins to affinity chromatography using as a ligand a monoclonal antibody against herps simplex virus glycoprotein gB, and adsorbing the resulting purified glycoprotein gB onto an aluminum gel to obtain a glycoprotein gB-adsorbed aluminum gel dispersion.
Claim 3
Dependent Claim
47 words
The method according to claim 1, wherein the solution containing herpes simplex virus glycoproteins is a solution obtained by subjecting particles of herpes simplex virus type 1 or type 2 or a virus envelope component of cells infected with the virus to dissolving treatment with a surfactant.
Claim 4
Dependent Claim
63 words
A herpes simplex virus subunit vaccine, which comprises as an essential active component glycoprotein gB produced by the method of subjecting a solution containing herpes simplex virus glycoproteins to affinity chromatography using as a ligand a monoclonal antibody against herpes simplex virus glycoprotein gB, and adsorbing the resulting purified glycoprotein gB onto an aluminum gel to obtain a glycoprotein gB-adsorbed aluminum gel dispersion.
Claim 5
Dependent Claim
63 words
A herpes simplex virus subunit vaccine, which comprises as an essential active component glycoprotein gB produced by the method of subjecting a solution containing herpes simplex virus glycoproteins to affinity chromatography using as a ligand a monoclonal antibody against herpes simplex virus glycoprotein gB, and adsorbing the resulting purified glycoprotein gB onto an aluminum gel to obtain a glycoprotein gB-adsorbed aluminum gel dispersion.
Claim 6
Dependent Claim
47 words
The vaccine according to claim 3, wherein the solution containing herpes simplex virus glycoproteins is a solution obtained by subjecting particles of herpes simplex virus type 1 or type 2 or a virus envelope component of cells infected with the virus to dissolving treatment with a surfactant.
References Cited (Backward Citations)
US4374127A
Cited
EP0001365A1
Cited
US4391911A
Cited
US4341754A
Cited
US4337242A
Cited
US4452734A
Cited
US4430437A
Cited
US4317811A
Cited
EP0048201A2
Cited
US4540669A
Cited
EP0065905A1
Cited
WO1983002897A1
Cited
US4535057A
Cited
EP0100521A2
Cited
EP0133063A1
Cited
US4533496A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-27 | 1990-10-27 | 1991-04-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-27 | 1994-10-27 | 1995-04-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-27 | 1998-10-27 | 1999-04-28 | $7700.00 | Window Closed / Lapsed |