Patent US2948058A successfully refreshed from Google Patents.
Patent US4676950A successfully refreshed from Google Patents.
US4676950A
Expired / Lapsed
US
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Indicator and test device for detecting occult blood
Assignee: Foster Research Corp
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Filing: 1984-02-03
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Granted: 1987-06-30
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Expires: 2004-02-03
Abstract
Abstract A test composition for detecting occult blood includes an alkaline water insoluble fraction of guaiac, an organic hydroperoxide containing a tertiary hydroperoxide group, and a buffer capable of maintaining the pH of material being tested within the range of about 4.5 to about 6.8, the purified guaiac, the hydroperoxide and the buffer being present in an amount effective to produce a color change in the presence of a hemoglobin-containing material. The test composition may be combined with a test substrate, preferably a matrix of bibulous or cellulosic material to provide a test device for detecting occult blood.
Inventors
- 👤 Raymond O. Foster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 20:55
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/72; G01N33/721; G01N33/726; G01N33/725
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
110 words
A substantially dry test device for detecting occult blood comprising: a test matrix of bibulous material impregnated with an indicator composition including: a color indicator consisting essentially of an alkaline water insoluble fraction of guaiac which is soluble in an organic solvent; an organic hydroperoxide containing a tertiary hydroperoxide group; and a buffer capable of maintaining the pH of a material being tested at a value within the range of about 4.5 to about 6.8, said organic hydroperoxide, said alkaline water insoluble fraction of guaiac and said buffer being present in amounts suitable to effect a color change in said test device in the presence of a hemoglobin containing material.
Claim 2
Dependent Claim
110 words
A substantially dry test device for detecting occult blood comprising: a test matrix of bibulous material impregnated with an indicator composition including: a color indicator consisting essentially of an alkaline water insoluble fraction of guaiac which is soluble in an organic solvent; an organic hydroperoxide containing a tertiary hydroperoxide group; and a buffer capable of maintaining the pH of a material being tested at a value within the range of about 4.5 to about 6.8, said organic hydroperoxide, said alkaline water insoluble fraction of guaiac and said buffer being present in amounts suitable to effect a color change in said test device in the presence of a hemoglobin containing material.
Claim 3
Dependent Claim
14 words
The test device according to claim 1 wherein said organic hydroperoxide is cumene hydroperoxide.
Claim 4
Dependent Claim
55 words
The test device according to claim 1 wherein said organic hydroperoxide is present in an amount of about 10 to about 60 parts and said buffer is present in an amount of about 1 to about 40 parts, all parts being by weight based on one part of said alkaline water insoluble fraction of guaiac.
Claim 5
Dependent Claim
40 words
The test device according to claim 1 wherein said bibulous material is paper and is present in an amount of about 50 to about 300 parts by weight, based on one part of the alkaline water insoluble fraction of guaiac.
Claim 6
Dependent Claim
22 words
The test device according to claim 1 further includng a binder effective to cause the indicator composition to adhere to said matrix.
Claim 7
Dependent Claim
11 words
The test device according to claim 1 further including an extender.
Claim 8
Dependent Claim
119 words
The test device according to claim 1 wherein said bibulous material is paper present in an amount of about 50 to about 300 parts by weight, based on one part of said alkaline water insoluble fraction of guaiac, said organic hydroperoxide is cumene hydroperoxide present in an amount of about 11.5 to about 50 parts by weight based on the weight of one part of said alkaline water insoluble fraction of guaiac, said buffer is a citric acid/citrate salt buffer system present in an amount of about 2 to about 25 parts by weight, based on the weight of one part of said alkaline water insoluble fraction of guaiac, and further including methyl cellulose, mannitol and polyoxyethylene sorbitan monoleate.
Claim 9
Dependent Claim
88 words
A test composition for detection of occult blood comprising: a color indicator consisting essentially of an alkaline water insoluble fraction of guaiac which is soluble in organic solvent; an organic hydroperoxide containing a tertiary hydroperoxide group; and a buffer capable of maintaining the pH of a material being tested within the range of about 4.5 to about 6.8, said alkaline water insoluble fraction of guaiac, said hydroperoxide and said buffer being present in amounts effective to produce a color change in the presence of a hemoglobin containing material.
Claim 10
Dependent Claim
88 words
A test composition for detection of occult blood comprising: a color indicator consisting essentially of an alkaline water insoluble fraction of guaiac which is soluble in organic solvent; an organic hydroperoxide containing a tertiary hydroperoxide group; and a buffer capable of maintaining the pH of a material being tested within the range of about 4.5 to about 6.8, said alkaline water insoluble fraction of guaiac, said hydroperoxide and said buffer being present in amounts effective to produce a color change in the presence of a hemoglobin containing material.
Claim 11
Dependent Claim
13 words
The test composition according to claim 8 wherein said hydroperoxide is cumene hydroperoxide.
Claim 12
Dependent Claim
53 words
The test composition according to claim 8 wherein said organic hydroperoxide is present in an amount of about 10 to about 60 parts and said buffer in an amount of about 1 to about 40 parts, all parts being by weight based on one part of said alkaline water insoluble fraction of guaiac.
Claim 13
Dependent Claim
13 words
The test composition according to claim 8 including a water miscible solvent system.
Claim 14
Dependent Claim
22 words
The test composition according to claim 8 further including a binder effective to cause the test composition to adhere to a matrix.
Claim 15
Dependent Claim
11 words
The test composition according to claim 8 further including an extender.
Claim 16
Dependent Claim
96 words
The test composition according to claim 8 wherein said organic hydroperoxide is cumene hydroperoxide present in an amount of about 11.5 to about 50 parts by weight, based on the weight of one part of said alkaline water insoluble fraction of guaiac, said buffer is a citric acid/citrate salt buffer system present in an amount of about 2 to about 25 parts by weight, based on the weight of one part of said alkaline water insoluble fraction of guaiac, and further including methyl cellulose, mannitol, and polyoxyethylene sorbitan monoleate and a mixture of ethanol and water.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-29 | 1990-12-29 | 1991-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-29 | 1994-12-29 | 1995-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-29 | 1998-12-29 | 1999-06-30 | $7700.00 | Window Closed / Lapsed |