Patent US4761490A successfully refreshed from Google Patents.
US4761490A
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Organic derivatives of tellurium and selenium and their use to stimulate cytokine production
Assignee: Bar-Ilan University
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Filing: 1985-09-30
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Granted: 1988-08-02
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Expires: 2005-09-30
Abstract
Abstract Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and their receptors. These compounds may be utilized in the treatment of certain tumors, autoimmune diseases, immune diseases and infectious diseases.
Inventors
- 👤 Michael Albeck
- 👤 Benjamin Sredni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 12:52
CPC Classifications
C; C07; C07D; C07D517/00; C07D517/02; C07D517/10; A; A61; A61K; A61K31/00; A61K31/095; A61K31/33; A61K31/66; A61K33/00; A61K33/04; A61P; A61P31/00; A61P31/12; A61P35/00; A61P37/00; A61P43/00; C07D329/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
173 words
A compound of the general formula: ##STR16## wherein Q is Te or Se; t is 1 or 0; u is 1 or 0; v is 1 or 0; R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or different and are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1 to 5 carbons, hydroxy, alkyl of from 1 to 5 carbon atoms, halogen, haloalkyl of 1 to 5 carbon atoms, carboxy, alkylcarbonylalkyl of 2 to 10 carbons, alkanoyloxy of 1 to 5 carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, acyl, amido, cyano, amidoalkyl of 1 to 5 carbons, N-monoalkylamidoalkyl of 2 to 10 carbons, N,N-dialkylamidoalkyl of 4 to 10 carbons, cyanoalkyl of 1 to 5 carbons, alkoxy of 1 to 5 carbon atoms, alkoxyalkyl of 2 to 10 carbon atoms and --COR 10 wherein R 10 is alkyl of from 1 to 5 carbons; and x is halogen;
Claim 2
Dependent Claim
173 words
A compound of the general formula: ##STR16## wherein Q is Te or Se; t is 1 or 0; u is 1 or 0; v is 1 or 0; R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or different and are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1 to 5 carbons, hydroxy, alkyl of from 1 to 5 carbon atoms, halogen, haloalkyl of 1 to 5 carbon atoms, carboxy, alkylcarbonylalkyl of 2 to 10 carbons, alkanoyloxy of 1 to 5 carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, acyl, amido, cyano, amidoalkyl of 1 to 5 carbons, N-monoalkylamidoalkyl of 2 to 10 carbons, N,N-dialkylamidoalkyl of 4 to 10 carbons, cyanoalkyl of 1 to 5 carbons, alkoxy of 1 to 5 carbon atoms, alkoxyalkyl of 2 to 10 carbon atoms and --COR 10 wherein R 10 is alkyl of from 1 to 5 carbons; and x is halogen;
Claim 3
Dependent Claim
16 words
A compound according to claim 1 which is of the formula: ##STR17## wherein X is halogen.
Claim 4
Dependent Claim
12 words
A compound according to claim 2 which is of the formula: ##STR18##
Claim 5
Dependent Claim
16 words
A compound according to claim 1 which is of the formula: ##STR19## wherein X is halogen.
Claim 6
Dependent Claim
12 words
A compound according to claim 4 which is of the formula: ##STR20##
Claim 7
Dependent Claim
169 words
A compound of the general formula: ##STR21## wherein t is 1 or 0; u is 1 or 0; v is 1 or 0; R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are the same or different and are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1 to 5 carbons, hydroxy, alkyl of from 1 to 5 carbon atoms, halogen, haloalkyl of 1 to 5 carbon atoms, carboxy, alkylcarbonylalkyl of 2 to 10 carbons, alknoyloxy of 1 to 5 carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, acyl, amido, cyano, amidoalkyl of 1 to 5 carbons, N-mono-alkylamidoalkyl of 2 to 10 carbons, N,N-dialkylamidoalkyl of 4 to 10 carbons, cyanoalkyl of 1 to 5 carbons, alkoxy of 1 to 5 carbon atoms, alkoxyalkyl of 2 to 10 carbon atoms and --COR 10 wherein R 10 is alkyl of from 1 to 5 carbons and X is Cl.
Claim 8
Dependent Claim
169 words
A compound of the general formula: ##STR21## wherein t is 1 or 0; u is 1 or 0; v is 1 or 0; R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are the same or different and are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1 to 5 carbons, hydroxy, alkyl of from 1 to 5 carbon atoms, halogen, haloalkyl of 1 to 5 carbon atoms, carboxy, alkylcarbonylalkyl of 2 to 10 carbons, alknoyloxy of 1 to 5 carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, acyl, amido, cyano, amidoalkyl of 1 to 5 carbons, N-mono-alkylamidoalkyl of 2 to 10 carbons, N,N-dialkylamidoalkyl of 4 to 10 carbons, cyanoalkyl of 1 to 5 carbons, alkoxy of 1 to 5 carbon atoms, alkoxyalkyl of 2 to 10 carbon atoms and --COR 10 wherein R 10 is alkyl of from 1 to 5 carbons and X is Cl.
Claim 9
Dependent Claim
175 words
A compound as defined in claim 6 which is of the formula: ##STR22## wherein t is 1 or 0; u is 1 or 0; v is 1 or 0; R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are the same or different and are independently selected from the group consisting of hydrogen, hydroxyalkyl of 1 to 5 carbons, hydroxy, alkyl of from 1 to 5 carbon atoms, halogen, haloalkyl of 1 to 5 carbon atoms, carboxy, alkylcarbonylalkyl of 2 to 10 carbons, alknoyloxy of 1 to 5 carbon atoms, carboxyalkyl of 1 to 5 carbon atoms, acyl, amido, cyano, amidoalkyl of 1 to 5 carbons, N-mono-alkylamidoalkyl of 2 to 10 carbons, N,N-dialkylamidoalkyl of 4 to 10 carbons, cyanoalkyl of 1 to 5 carbons, alkoxy of 1 to 5 carbon atoms, alkoxyalkyl of 2 to 10 carbon atoms and --COR 10 wherein R 10 is alkyl of from 1 to 5 carbons and X is Cl.
References Cited (Backward Citations)
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