US4772475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled-release multiple units pharmaceutical formulation
Assignee: Astellas Pharma Inc
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Filing: 1986-02-27
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Granted: 1988-09-20
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Expires: 2006-02-27
Abstract
Abstract A pharmaceutical controlled-release individual unit or multiple units formulation in which the individual unit comprises a granulation product obtained by adding a release controlling agent to a mixture of a physiologically active substance and units-forming substance(s) and granulating and resultant mixture, said granulation product (granules) being substantially not disintegrated but gradually releasing the physiologically active substance in the gastrointestinal tract.
Inventors
- 👤 Muneo Fukui
- 👤 Kouji Tomuro
- 👤 Shigeru Masuyama
- 👤 Atsushi Kajiyama
- 👤 Tamio Hikosaka
- 👤 Masayoshi Aruga
- 👤 Saburo Higuchi
- 👤 Yoshiaki Soeishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2077; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1635; A61K9/1652
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
100 words
A pharmaceutical controlled-release individual unit or multiple unit formulation in which said individual unit consists essentially a granulation product obtained by adding a release controlling agent selected from the group consisting of acrylic acid polymers, acrylic acid copolymers and mixtures thereof with cellulose derivatives, to a mixture of physiologically active substances and crystalline cellulose, in an amount such that at least 50% by weight based on the weight of the units is said crystalline cellulose and granulating the resultant mixture and wherein said granulation product does not substantially disintegrate but gradually releases the physiologically active substance in the gastrointestinal tract.
Claim 2
Dependent Claim
100 words
A pharmaceutical controlled-release individual unit or multiple unit formulation in which said individual unit consists essentially a granulation product obtained by adding a release controlling agent selected from the group consisting of acrylic acid polymers, acrylic acid copolymers and mixtures thereof with cellulose derivatives, to a mixture of physiologically active substances and crystalline cellulose, in an amount such that at least 50% by weight based on the weight of the units is said crystalline cellulose and granulating the resultant mixture and wherein said granulation product does not substantially disintegrate but gradually releases the physiologically active substance in the gastrointestinal tract.
Claim 3
Dependent Claim
27 words
The pharmaceutical formulation as claimed in claim 1, wherein the release controlling agent is a methacrylic acid-ethyl acrylate copolymer or mixtures of said copolymer and ethyl cellulose.
Claim 4
Dependent Claim
16 words
The pharmaceutical formulation as claimed in claim 1, wherein the release controlling agent further contains water.
Claim 5
Dependent Claim
20 words
The pharmaceutical formulation as claimed in claim 1, 2, or 3, wherein the physiologically active substance is 5-{2-[2-(o-ethoxypheoxy)ethylamino]propyl}-2-methoxybenzenesulfonamide hydrochloride (YM-12617).
Claim 6
Dependent Claim
26 words
The pharmaceutical formulation as claimed in claim 1, 2, 3, or 4, wherein the individual unit is granulation product having diameter of 0.1 to 1.5 mm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |