Quinoline antibacterial compounds

Claim 1

A compound having the formula: ##STR53## wherein R 1 is hydrogen or a carboxy protecting group; R is phenyl having the formula: ##STR54## wherein R 2 is methylenedioxy or one or two substituents independently selected from hydrogen, halogen, nitro, carboxyl, cyano, C 1 to C 6 alkyl, hydroxy-substituted C 1 to C 6 alkyl, halo substituted C 1 to C 6 alkyl, a substituent having the formula: --Y--R.sub.3 wherein --Y-- is --O-- or --S-- and R 3 is hydrogen or C 1 to C 6 alkyl, and a substituent of the formula: ##STR55## wherein R 4 and R 5 are independently hydrogen or C 1 or C 6 alkyl; and, Z is selected from (1) an aliphatic heterocyclic ring having the structure: ##STR56## wherein R 8 is CH 2 , (CH 2 ) 2 , or -CH 2 R 9 (CH 2 ) n - wherein R 9 is selected from the group consisting of --S, --O-- and --N-- and n is O or 1; (2) substituted derivatives of said aliphatic heterocyclic ring having one or two substitutents independently selected from C 1 to C 6 alkyl, C 1 to C 6 hydroxyalkyl, hydroxy, alkanoyl having 1 to 6 carbon atoms, alkanoylamino having 1 to 6 carbon atoms and a substituent of the formula: ##STR57## wherein R 10 and R 11 are each independently selected from hydrogen, C 1 to C 6 alkyl, halo-substituted C 1 to C 6 alkyl and hydroxy-substituted C 1 to C 6 alkyl; and (3) a substituent of the formula: ##STR58## wherein R 6 is hydrogen, C 1 to C 10 alkyl, halo-substituted C 1 to C 10 alkyl or hydroxy-substituted C 1 to C 10 alkyl, and R 7 is selected from C 1 to C 10 alkyl, halo-substituted C 1 to C 10 alkyl, hydroxy-substituted C 1 to C 10 alkyl, --NH 2 , a mono-(C 1 to C 6 ) alkylamino and a di-(C 1 to C 6 ) alkylamino; and pharmaceutically acceptable salts thereof.