US4851554A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Certain 3-substituted 2-alkyl benzofuran derivatives
Assignee: Research Corp Technologies Inc
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Filing: 1987-09-30
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Granted: 1989-07-25
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Expires: 2007-09-30
Abstract
Abstract The disclosure relates to compounds of the formula ##STR1## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, wherein R 5 is a lower alkyl group, wherein R 6 is either hydrogen or methyl, wherein Am is selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazino, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y 1 and Y 2 are identical and are hydrogen, a halogen, methyl or ethyl048505325 and n is an integer in the range of 1-5.
Inventors
- 👤 Thomas P. Kennedy
- 👤 George W. Kabalka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 19:34
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80; A; A61; A61P; A61P9/00; A61P9/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
135 words
A compound of the formula: ##STR30## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, where such substituents are one or more members selected from the group consisting of branched or straight-chain alkyl, cycloalkyl, aryl, alkoxy, and ##STR31## with R 4 being hydrogen or lower alkyl, wherein R 5 is a lower alkyl group, wherein R 6 is either hydrogen or methyl, wherein Am is a group selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazine, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, halogen, methyl and ethyl and n is an integer in the range of 1-5.
Claim 2
Dependent Claim
135 words
A compound of the formula: ##STR30## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, where such substituents are one or more members selected from the group consisting of branched or straight-chain alkyl, cycloalkyl, aryl, alkoxy, and ##STR31## with R 4 being hydrogen or lower alkyl, wherein R 5 is a lower alkyl group, wherein R 6 is either hydrogen or methyl, wherein Am is a group selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazine, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, halogen, methyl and ethyl and n is an integer in the range of 1-5.
Claim 3
Dependent Claim
126 words
A compound as set forth in claim 1 wherein X represents an alkylene chain having the ##STR32## wherein either R 1 or R 2 is hydrogen and the other of R 1 or R 2 is selected from the class consisting of hydrogen, a group having the formula --OR 3 with R 3 being a lower alkyl group, and a group having the ##STR33## with R 4 being hydrogen or a lower alkyl group, R 5 is butyl, R 6 is hydrogen, Am is selected from the class consisting of amino and lower mono and dialkylamino and Y 1 Y 2 are identical and are selected from the class consisting of hydrogen, bromine, iodine, and methyl and n is an integer in the range of 1-3.
Claim 4
Dependent Claim
104 words
A compound as set forth in claim 2 wherein R 2 is hydrogen and R 1 is selected from the class consisting of hydrogen, a group having the formula --OR 3 with R 3 being a lower alkyl group, and a group having the ##STR34## with R 4 being hydrogen or a lower alkyl group, R 5 is butyl, R 6 is hydrogen, Am is selected from the class consisting of amino, ethylamino, and dialkylamino, Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, iodine, and methyl and n is an integer in the range of 1-3.
Claim 5
Dependent Claim
92 words
A compound as set forth in claim 2 wherein R 2 is hydrogen and R 1 is selected from the class consisting of hydrogen, --OR 3 with R 3 being a lower alkyl group containing between 1 and 4 carbon atoms, ##STR35## with R 4 being hydrogen or a lower alkyl containing 1-4 carbon atoms, R 5 is n-butyl, R 6 is hydrogen, Am is amino, ethylamino or diethylamino, Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, iodine, and methyl, and n is 1.
Claim 6
Dependent Claim
17 words
A compound as set forth in claim 4 wherein both R 1 and R 2 are hydrogen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |