Patent US4851554A successfully refreshed from Google Patents.
US4851554A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Certain 3-substituted 2-alkyl benzofuran derivatives
Assignee: Research Corp Technologies Inc
•
Filing: 1987-09-30
•
Granted: 1989-07-25
•
Expires: 2007-09-30
Abstract
Abstract The disclosure relates to compounds of the formula ##STR1## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, wherein R 5 is a lower alkyl group, wherein R 6 is either hydrogen or methyl, wherein Am is selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazino, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y 1 and Y 2 are identical and are hydrogen, a halogen, methyl or ethyl048505325 and n is an integer in the range of 1-5.
Inventors
- 👤 Thomas P. Kennedy
- 👤 George W. Kabalka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:22
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/79; C07D307/80; A; A61; A61P; A61P9/00; A61P9/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
135 words
A compound of the formula: ##STR30## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, where such substituents are one or more members selected from the group consisting of branched or straight-chain alkyl, cycloalkyl, aryl, alkoxy, and ##STR31## with R 4 being hydrogen or lower alkyl, wherein R 5 is a lower alkyl group, wherein R 6 is either hydrogen or methyl, wherein Am is a group selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazine, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, halogen, methyl and ethyl and n is an integer in the range of 1-5.
Claim 2
Dependent Claim
135 words
A compound of the formula: ##STR30## and pharmaceutically acceptable addition salts thereof wherein X represents a single, direct bond or a substituted or unsubstituted alkylene chain containing 1 to 4 carbon atoms, where such substituents are one or more members selected from the group consisting of branched or straight-chain alkyl, cycloalkyl, aryl, alkoxy, and ##STR31## with R 4 being hydrogen or lower alkyl, wherein R 5 is a lower alkyl group, wherein R 6 is either hydrogen or methyl, wherein Am is a group selected from the class consisting of amino, lower mono and dialkylamino, piperidino, piperazine, N-lower alkyl piperazino, pyrrolidino, and morpholino groups, wherein Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, halogen, methyl and ethyl and n is an integer in the range of 1-5.
Claim 3
Dependent Claim
126 words
A compound as set forth in claim 1 wherein X represents an alkylene chain having the ##STR32## wherein either R 1 or R 2 is hydrogen and the other of R 1 or R 2 is selected from the class consisting of hydrogen, a group having the formula --OR 3 with R 3 being a lower alkyl group, and a group having the ##STR33## with R 4 being hydrogen or a lower alkyl group, R 5 is butyl, R 6 is hydrogen, Am is selected from the class consisting of amino and lower mono and dialkylamino and Y 1 Y 2 are identical and are selected from the class consisting of hydrogen, bromine, iodine, and methyl and n is an integer in the range of 1-3.
Claim 4
Dependent Claim
104 words
A compound as set forth in claim 2 wherein R 2 is hydrogen and R 1 is selected from the class consisting of hydrogen, a group having the formula --OR 3 with R 3 being a lower alkyl group, and a group having the ##STR34## with R 4 being hydrogen or a lower alkyl group, R 5 is butyl, R 6 is hydrogen, Am is selected from the class consisting of amino, ethylamino, and dialkylamino, Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, iodine, and methyl and n is an integer in the range of 1-3.
Claim 5
Dependent Claim
92 words
A compound as set forth in claim 2 wherein R 2 is hydrogen and R 1 is selected from the class consisting of hydrogen, --OR 3 with R 3 being a lower alkyl group containing between 1 and 4 carbon atoms, ##STR35## with R 4 being hydrogen or a lower alkyl containing 1-4 carbon atoms, R 5 is n-butyl, R 6 is hydrogen, Am is amino, ethylamino or diethylamino, Y 1 and Y 2 are identical and are selected from the class consisting of hydrogen, iodine, and methyl, and n is 1.
Claim 6
Dependent Claim
17 words
A compound as set forth in claim 4 wherein both R 1 and R 2 are hydrogen.
References Cited (Backward Citations)
US3248401A
Cited
US3929836A
Cited
US3627763A
Cited
US3818035A
Cited
US3810991A
Cited
US3917600A
Cited
US3891648A
Cited
US3920707A
Cited
US3931240A
Cited
US4007204A
Cited
US3972900A
Cited
US4485112A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-24 | 1993-01-23 | 1993-07-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-24 | 1997-01-23 | 1997-07-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-24 | 2001-01-23 | 2001-07-25 | $7700.00 | Window Closed / Lapsed |