1-aryl-4-quinolone-3-carboxylic acids

Claim 1

A 1-aryl-4-quinoline-3-carboxylic acid of the formula ##STR85## in which X 1 is chlorine, fluorine or nitro, X 2 is chlorine or fluorine with the proviso that X 1 and X 2 are not simultaneously fluorine, R is phenyl, or phenyl substituted by at least one of halogen, alkyl with 1 to 4 carbon atoms, alkoxy, alkylmercapto or alkylsulphonyl with in each case up to 3 carbon atoms, nitro, cyano, carboxyl, methylenedioxy, a pyridine, thiophene, furan or thiazole radical, or an amine radical of the formula ##STR86## R 5 and R 6 each independently is hydrogen, or alkyl with 1 to 3 carbon atoms, A is ##STR87## or halogen, R 1 is hydrogen, alkyl with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms and substituted by a hydroxyl or methoxy group, phenacyl, phenacyl substituted by hydroxyl, methoxy, chlorine or fluorine, an oxoalkyl radical with 2 to 4 carbon atoms, 4-aminobenzyl, formyl or acetyl, or the radical ##STR88## R 2 is hydrogen, methyl, phenyl, thienyl, or phenyl or thienyl substituted by chlorine, fluorine, methyl, hydroxyl or methoxy, R 3 is hydrogen or methyl, and R 4 is hydrogen, hydroxyl amino, alkyl- or dialkylamino with 1 or 2 carbon atoms in each alkyl group, hydroxymethyl, aminomethyl or alkyl- or dialkylaminomethyl with 1 or 2 carbon atoms in each alkyl group, or a pharmaceutically usable hydrate, acid addition salt, alkali metal, alkaline earth metal, silver or guanidinium salt thereof, and/or an C 1 -C 3 -alkyl ester thereof.