US5036153A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
Assignee: Pfizer Inc
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Filing: 1989-10-18
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Granted: 1991-07-30
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Expires: 2009-10-18
Abstract
Abstract Diazabicyclo[2.2.1]heptane intermediates are prepared from 4-hydroxy-L-proline in a five step procedure, or from allo-4-hydroxy-D-proline, through a novel 2-(C1-c6)alkyl-5-substituted-2,5-diazabicyclo[2.2.1]heptane intermediate. The diazabicycloheptanes are of use in the preparation of antibiotic quinolones.
Inventors
- 👤 Tamim F. Braish
- 👤 Darrell E. Fox
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 05:49
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/08; A; A61; A61P; A61P31/00; A61P31/04; C07D207/00; C07D207/46; C07D207/48; C07D487/06
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
82 words
A process for preparing a compound of the formula ##STR16## wherein X is SO 2 or CO 2 , and R 2 is C 1 -C 6 alkyl, trifluoromethyl, benzyl, or phenyl or phenyl substituted by one or two C 1 -C 6 alkyl, halogen, nitro, methoxy, or trifluoromethyl, which comprises heating a compound of the formula ##STR17## wherein X and R 2 are as defined above, with tosylchloride in pyridine at a temperature of about 70 ° to about 115° C.
Claim 2
Dependent Claim
82 words
A process for preparing a compound of the formula ##STR16## wherein X is SO 2 or CO 2 , and R 2 is C 1 -C 6 alkyl, trifluoromethyl, benzyl, or phenyl or phenyl substituted by one or two C 1 -C 6 alkyl, halogen, nitro, methoxy, or trifluoromethyl, which comprises heating a compound of the formula ##STR17## wherein X and R 2 are as defined above, with tosylchloride in pyridine at a temperature of about 70 ° to about 115° C.
Claim 3
Dependent Claim
16 words
A process according to claim 1 wherein X is SO 2 and R 2 is p-tolyl.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-07-29 | 1995-01-28 | 1995-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-29 | 1999-01-28 | 1999-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-29 | 2003-01-28 | 2003-07-30 | $7700.00 | Window Closed / Lapsed |