US5120719A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Conjugate of prostaglandin and polysaccharide
Assignee: Eisai R&D Management Co Ltd
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Filing: 1989-11-15
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Granted: 1992-06-09
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Expires: 2009-11-15
Abstract
Abstract A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2α, prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.
Inventors
- 👤 Kiyoshi Iwamoto
- 👤 Masahiro Kawahara
- 👤 Sumio Watanabe
- 👤 Yasuo Miyake
- 👤 Fumio Sagami
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:54
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61P; A61P43/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
50 words
A stabilized prostaglandin composition comprising a prostaglandin compound selected from the group consisting of prostaglandin E 1 , prostaglandin E 2 , prostaglandin F 2 α, prostaglandin I2, carbacycline and iloprost covalently bonded to a polysaccharide selected from the group consisting of pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.
Claim 2
Dependent Claim
50 words
A stabilized prostaglandin composition comprising a prostaglandin compound selected from the group consisting of prostaglandin E 1 , prostaglandin E 2 , prostaglandin F 2 α, prostaglandin I2, carbacycline and iloprost covalently bonded to a polysaccharide selected from the group consisting of pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.
Claim 3
Dependent Claim
25 words
The composition of claim 1, in which 0.05 to 20 molecules of the prostaglandin compound are covalently bonded per 100 monosaccharide molecules of said polysaccharide.
Claim 4
Dependent Claim
25 words
The composition of claim 1, in which 0.05 to 5 molecules of the prostaglandin compound are covalently bonded per 100 monosaccharide molecules of said polysaccharide.
Claim 5
Dependent Claim
22 words
The composition of claim 1, in which the polysaccharide has a molecular weight in a range of from about 10,000 to 150,000.
Claim 6
Dependent Claim
17 words
The composition of claim 1, in which the prostaglandin compound is iloprost and the polysaccharide is dextran.
Claim 7
Dependent Claim
17 words
The composition of claim 1, in which the prostaglandin compound is iloprost and the polysaccharide is pluran.
Claim 8
Dependent Claim
18 words
The composition of claim 1, in which the prostaglandin compound is iloprost and the polysaccharide is hydroxyethylated starch.
Claim 9
Dependent Claim
19 words
The composition of claim 1, in which the prostaglandin compound is prostaglandin E 1 and the polysaccharide is dextran.
Claim 10
Dependent Claim
19 words
The composition of claim 1, in which the prostaglandin compound is prostaglandin E 2 and the polysaccharide is dextran.
Claim 11
Dependent Claim
20 words
The composition of claim 1, in which the prostaglandin compound is prostaglandin F 2 α and the polysaccharide is dextran.
Claim 12
Dependent Claim
19 words
The composition of claim 1, in which the prostaglandin compound is prostaglandin E 1 and the polysaccharide is pluran.
Claim 13
Dependent Claim
20 words
The composition of claim 1, in which the prostaglandin compound is prostaglandin E 2 and the polysaccharide is hydroxyethylated starch.
References Cited (Backward Citations)
US4036954A
Cited
US4092428A
Cited
US4113882A
Cited
US4066787A
Cited
US4352790A
Cited
US4675182A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-09 | 1995-12-09 | 1996-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-09 | 1999-12-09 | 2000-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-09 | 2003-12-09 | 2004-06-09 | $7700.00 | Window Closed / Lapsed |