Layered mixed metal hydroxides for the stabilization of radioactive colloids

Claim 2

A composition comprising: a colloid capable of being labeled with a radionuclide; a radionuclide; and a layered mixed metal hydroxide having the formula: Li.sub.m D.sub.d T(OH).sub.(m+2d+3+na) A.sub.a.sup.n wherein: m is 0 to about 1; D is a divalent metal ion selected from the group consisting of magnesium, calcium, barium, strontium, manganese, iron, cobalt, nickel, copper, and zinc or a mixture thereof; d is 0 to about 4; provided that both m and d are not 0; T is a metal ion selected from the group consisting of aluminum, gallium, chromium, and iron; A is a monovalent or polyvalent ion other than a hydroxyl ion; n is the valence of the anion A; a is the number of anions A in the formula; (m+2d+3+na) and is equal to or greater than 3.

Claim 3

The composition of claim 1 wherein said colloid is bentonite.

Claim 4

The composition of claim 1 wherein m is zero.

Claim 5

The composition of claim 1 wherein m is approximately 0.5 to approximately 0.75.

Claim 6

The composition of claim 1 wherein D is magnesium, calcium, or mixtures thereof.

Claim 7

The composition of claim 1 wherein d is approximately 1 to approximately 3.

Claim 8

The composition of claim 1 wherein T is aluminum or iron.

Claim 9

The composition of claim 1 wherein d is 1.

Claim 10

The composition of claim 8 wherein T is aluminum.

Claim 11

The composition of claim 1 wherein the radionuclide is a radioactive metal.

Claim 12

The composition of claim 10 wherein the radionuclide is Sm-153, Ho-166, Lu-177, La-140, Gd-159, Yb-175, In-115m, Y-90, Sc-47, Re-186, or Re-188.

Claim 13

The composition of claim 1 wherein said colloid is a metal hydroxide.

Claim 14

The composition of claim 12 wherein said metal hydroxide is iron hydroxide.

Claim 15

The composition of claim 13 wherein said iron hydroxide is iron (II) hydroxide.

Claim 16

The composition of claim 13 wherein said iron hydroxide is iron (III) hydroxide.

Claim 17

The composition of claim 1 further comprising an ion exchange medium.

Claim 18

The composition of claim 16 wherein the ion exchange medium is a negatively charged clay.

Claim 19

The composition of claim 17 wherein the negatively charged clay is bentonite.

Claim 20

The composition of claim 1 wherein m is 0, D is magnesium, and T is aluminum.

Claim 21

The composition of claim 19 wherein said layered mixed metal hydroxide has the formula: Mg.sub.x Al.sub.y (OH).sub.z A.sub.a.sup.n wherein: x is approximately 1 to approximately 3; y is approximately 1; z is approximately 3 to approximately 5; A is a halide, sulfate, phosphate, or carbonate; n is the valence of A; and a is approximately 0.1 to 1.0.

Claim 22

The composition of claim 20 wherein x is 1, y is 1, z is 4.7, and a is 0.3.

Claim 23

The composition of claim 21 wherein the radionuclide is Sm-153 or Ho-166.

Claim 24

A therapeutic radiation ablation treatment method comprising: injecting into a synovium of a subject in need of such treatment a therapeutically effective amount of a stabilized radioactive colloid composition wherein the radioactive colloid composition contains a layered mixed metal hydroxide; wherein the layered mixed metal hydroxide has the formula: Li.sub.m D.sub.d T(OH).sub.(m+2d+3+na) A.sub.a.sup.n wherein: m is in the range of 0 to approximately 1; D is a divalent metal ion selected from the group consisting of magnesium, calcium, barium, strontium, manganese, iron, cobalt, nickel, copper, and zinc or a mixture thereof; d is 0 to about 4; provided that m and d are not both 0; T is a metal ion selected from the group consisting of aluminum, gallium, chromium, and iron; A is a monovalent or polyvalent ion other than an hydroxyl ion; n is the valence of the anion A; a is the number of anions A in the formula; and (m+2d+3+na) is equal to or greater than 3.

Claim 25

A therapeutic radiation ablation treatment method comprising: injecting into a synovium of a subject in need of such treatment a therapeutically effective amount of a stabilized radioactive colloid composition wherein the radioactive colloid composition contains a layered mixed metal hydroxide; wherein the layered mixed metal hydroxide has the formula: Li.sub.m D.sub.d T(OH).sub.(m+2d+3+na) A.sub.a.sup.n wherein: m is in the range of 0 to approximately 1; D is a divalent metal ion selected from the group consisting of magnesium, calcium, barium, strontium, manganese, iron, cobalt, nickel, copper, and zinc or a mixture thereof; d is 0 to about 4; provided that m and d are not both 0; T is a metal ion selected from the group consisting of aluminum, gallium, chromium, and iron; A is a monovalent or polyvalent ion other than an hydroxyl ion; n is the valence of the anion A; a is the number of anions A in the formula; and (m+2d+3+na) is equal to or greater than 3.

Claim 26

The method of claim 23 wherein: m is in the range of approximately 0.5 to 0.75; D is Mg, Ca, or a mixture thereof; d is in the range of approximately 1 to 3; and T is a halide, sulfate, or phosphate.

Claim 27

The method of claim 23 wherein said administering is to a patient suffering from arthritis.

Claim 28

The method of claim 25 wherein said arthritis is rheumatoid arthritis.

Claim 29

The method of claim 23 wherein said radioactive colloid composition further contains a negatively charged clay.

Claim 30

The method of claim 27 wherein said clay is bentonite.

Claim 31

The method of claim 23 wherein said layered mixed metal hydroxide has the formula: Mg.sub.x Al.sub.y (OH).sub.z A.sub.a.sup.n wherein: x is approximately 1 to approximately 3; y is approximately 1; z is approximately 3 to approximately 5; A is a halide, sulfate, phosphate, or carbonate; n is the valence of A; and a is approximately 0.1 to 1.0.

Claim 32

The method of claim 29 wherein x is 1, y is 1, z is 4.7, and a is 0.3.

Claim 33

The method of claim 23 wherein said administering is of a radioactive colloid composition which contains a radioactive metal.

Claim 34

The method of claim 31 wherein the radioactive metal is Sm-153, Ho-166, Lu-177, La-140, Gd-159, Yb-174, In-115m, Y-90, Sc-47, Re-186, or Re-188.

Claim 35

The method of claim 32 wherein the radioactive metal is Sm-153.

Claim 36

The method of claim 32, wherein the radioactive metal is Ho-166.