Patent US5145643A successfully refreshed from Google Patents.
US5145643A
Expired / Lapsed
US
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Nonoxidative ophthalmic compositions and methods for preserving and using same
Assignee: Johnson and Johnson Surgical Vision Inc
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Filing: 1990-01-05
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Granted: 1992-09-08
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Expires: 2010-01-05
Abstract
Abstract Ophthalmic compositions, such as those used to care for contact lenses, methods of preserving such compositions, and methods for disinfecting contact lenses using such compositions are disclosed. The compositions may comprise an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective preserving or disinfecting amount of certain oxygen-containing ionene polymers.
Inventors
- 👤 Anthony J. Dziabo
- 👤 Michelle P. Wong
- 👤 Peter Gyulai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:06
CPC Classifications
A; A01; A01N; A01N33/00; A01N33/02; A01N33/12; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/143; A61L12/145
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
58 words
A method for disinfecting a contact lens comprising: contacting a contact lens with a substantially non-oxidative composition including an effective disinfecting amount of an ophthalmically acceptable, quaternary ammonium polymer selected from the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, at conditions to effectively disinfect said contact lens.
Claim 2
Independent Claim
58 words
A method for disinfecting a contact lens comprising: contacting a contact lens with a substantially non-oxidative composition including an effective disinfecting amount of an ophthalmically acceptable, quaternary ammonium polymer selected from the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, at conditions to effectively disinfect said contact lens.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein said composition includes a liquid aqueous medium and an effective pH buffering amount of buffer.
Claim 4
Dependent Claim
36 words
The method of claim 2 wherein said quaternary ammonium polymer is present during said contacting in an amount in the range of about 0.00001% to about 1% by weight per volume of said liquid aqueous medium.
Claim 5
Dependent Claim
34 words
The method of claim 2 wherein said contact lens after being disinfected is contacted with a second liquid aqueous medium prior to being placed in the eye of the wearer of said contact lens.
Claim 6
Dependent Claim
40 words
The method of claim 1 which further comprises contacting said contact lens in a liquid medium with at least one enzyme capable of removing debris from a contact lens in an amount effective to remove debris from said contact lens.
Claim 7
Dependent Claim
23 words
The method of claim 5 wherein said contact lens-quaternary ammonium polymer contacting and said contact lens-enzyme contacting occur at substantially the same time.
Claim 8
Dependent Claim
35 words
The method of claim 2 where said quaternary ammonium polymer has a molecular weight in the range of about 500 to about 5000 and said composition includes an effective pH buffering amount of borate buffer.
Claim 9
Dependent Claim
108 words
The method of claim 1 wherein said quaternary ammonium polymer has a repeating unit ##STR3## wherein R 1 , R 4 and R 6 are each independently selected from the group consisting of alkylene radicals containing 1 to about 6 carbon atoms, R 2 , R 3 , R 5 and R 7 are each independently selected from alkyl radicals containing 1 to about 6 carbon atoms, each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is an integer in the range of about 5 to about 30.
Claim 10
Dependent Claim
57 words
The method of claim 1 wherein said quaternary ammonium polymer has a repeating unit ##STR4## wherein each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is an integer in the range of about 8 to about 30.
Claim 11
Dependent Claim
17 words
The method of claim 9 wherein each A - is Cl - and x is about 14.
Claim 12
Dependent Claim
18 words
The method of claim 1 wherein said quaternary ammonium polymer is poly (oxyethylene (dimethylimino) ethylene dimethylimino) ethylene dichloride.
Claim 13
Independent Claim
67 words
A method for preserving an ophthalmically acceptable medium comprising: contacting a substantially non-oxidative ophthalmically acceptable medium useful in caring for a contact lens with an effective preserving amount of an ophthalmically acceptable, quaternary ammonium polymer selected for the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, at conditions to effectively preserve said substantially non-oxidative, ophthalmically acceptable medium.
Claim 14
Independent Claim
67 words
A method for preserving an ophthalmically acceptable medium comprising: contacting a substantially non-oxidative ophthalmically acceptable medium useful in caring for a contact lens with an effective preserving amount of an ophthalmically acceptable, quaternary ammonium polymer selected for the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, at conditions to effectively preserve said substantially non-oxidative, ophthalmically acceptable medium.
Claim 15
Dependent Claim
12 words
The method of claim 12 wherein said ophthalmically acceptable medium is sterile.
Claim 16
Dependent Claim
24 words
The method of claim 12 wherein said ophthalmically acceptable medium is a liquid aqueous medium and includes an effective pH buffering amount of buffer.
Claim 17
Dependent Claim
36 words
The method of claim 12 wherein said quaternary ammonium polymer is present during said contacting in an amount in the range of about 0.00001% to about 1% by weight per volume of said ophthalmically acceptable medium.
Claim 18
Dependent Claim
37 words
The method of claim 14 where said quaternary ammonium polymer has a molecular weight in the range of about 500 to about 5000 and said liquid aqueous medium includes an effective pH buffering amount of borate buffer.
Claim 19
Dependent Claim
108 words
The method of claim 12 wherein said quaternary ammonium polymer has a repeating unit ##STR5## wherein R 1 , R 4 and R 6 are each independently selected from the group consisting of alkylene radicals containing 1 to about 6 carbon atoms, R 2 , R 3 , R 5 and R 7 are each independently selected from alkyl radicals containing 1 to about 6 carbon atoms, each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is an integer in the range of about 5 to about 30.
Claim 20
Dependent Claim
57 words
The method of claim 12 wherein said quaternary ammonium polymer has a repeating unit ##STR6## wherein each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is a integer in the range of about 8 to about 30.
Claim 21
Dependent Claim
17 words
The method of claim 18 wherein each A - is Cl - and x is about 14.
Claim 22
Dependent Claim
18 words
The method of claim 12 wherein said quaternary ammonium polymer is poly (oxyethylene (dimethylimino) ethylene dimethylimino) ethylene dichloride.
Claim 23
Dependent Claim
65 words
A composition useful for disinfecting a contact lens comprising an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective contact lens disinfecting amount of an ophthalmically acceptable, quaternary ammonium polymer selected from the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, and an effective pH buffering amount of buffer, said composition being substantially non-oxidative.
Claim 24
Dependent Claim
65 words
A composition useful for disinfecting a contact lens comprising an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective contact lens disinfecting amount of an ophthalmically acceptable, quaternary ammonium polymer selected from the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, and an effective pH buffering amount of buffer, said composition being substantially non-oxidative.
Claim 25
Dependent Claim
35 words
The method of claim 21 wherein said quaternary ammonium polymer is present in an amount in the range of about 0.00001% to about 1% by weight per volume of said ophthalmically acceptable liquid aqueous medium.
Claim 26
Dependent Claim
33 words
The composition of claim 21 which further comprises at least one enzyme capable of removing debris from a contact lens in an amount effective to remove debris from a debris laden contact lens.
Claim 27
Dependent Claim
35 words
The composition of claim 21 where said quaternary ammonium polymer has a molecular weight in the range of about 500 to about 5000, and said composition comprises an effective pH buffering amount of borate buffer.
Claim 28
Dependent Claim
108 words
The composition of claim 21 wherein said quaternary ammonium polymer has a repeating unit ##STR7## wherein R 1 , R 4 and R 6 are each independently selected from the group consisting of alkylene radicals containing 1 to about 6 carbon atoms, R 2 , R 3 , R 5 and R 7 are each independently selected from alkyl radicals containing 1 to about 6 carbon atoms, each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is an integer in the range of about 5 to about 30.
Claim 29
Dependent Claim
56 words
The composition of claim 21 wherein said quaternary ammonium polymer has a repeating unit ##STR8## wherein A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is a integer in the range of about 8 to about 30.
Claim 30
Dependent Claim
17 words
The composition of claim 26 wherein each A - is Cl - and x is about 14.
Claim 31
Dependent Claim
18 words
The composition of claim 21 wherein said quaternary ammonium polymer is poly (oxyethylene (dimethylimino) ethylene dimethylimino) ethylene dichloride.
Claim 32
Dependent Claim
63 words
A preserved composition comprising an ophthalmically acceptable medium useful in caring for a contact lens and, included therein, an effective preserving amount of an ophthalmically acceptable, quaternary ammonium polymer selected from the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, and an effective pH buffering amount of buffer, said composition being substantially non-oxidative.
Claim 33
Dependent Claim
63 words
A preserved composition comprising an ophthalmically acceptable medium useful in caring for a contact lens and, included therein, an effective preserving amount of an ophthalmically acceptable, quaternary ammonium polymer selected from the group consisting of ionene polymers containing an oxygen atom covalently bonded to two carbon atoms and mixtures thereof, and an effective pH buffering amount of buffer, said composition being substantially non-oxidative.
Claim 34
Dependent Claim
10 words
The composition of claim 29 wherein said composition is sterile.
Claim 35
Dependent Claim
15 words
The composition of claim 29 wherein said ophthalmically acceptable medium is a liquid aqueous medium.
Claim 36
Dependent Claim
15 words
The composition of claim 29 wherein said ophthalmically acceptable medium is a liquid aqueous medium.
Claim 37
Dependent Claim
33 words
The composition of claim 29 wherein said quaternary ammonium polymer is present in an amount in the range of about 0.00001% to about 1% by weight per volume of said ophthalmically acceptable medium.
Claim 38
Dependent Claim
35 words
The composition of claim 32 wherein said quaternary ammonium polymer has a molecular weight in the range of about 500 to about 5000, and said composition comprises an effective pH buffering component of borate buffer.
Claim 39
Dependent Claim
108 words
The composition of claim 29 wherein said quaternary ammonium polymer has a repeating unit ##STR9## wherein R 1 , R 4 and R 6 are each independently selected from the group consisting of alkylene radicals containing 1 to about 6 carbon atoms, R 2 , R 3 , R 5 and R 7 are each independently selected from alkyl radicals containing 1 to about 6 carbon atoms, each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said quaternary ammonium polymer and is an integer in the range of about 8 to about 30.
Claim 40
Dependent Claim
57 words
The composition of claim 19 wherein said quaternary ammonium polymer has a repeating unit ##STR10## wherein each A - is independently selected from the group consisting of ophthalmically acceptable anions, and x is the number of said repeating units in said oxygen-containing ionene polymer and is a integer in the range of about 8 to about 30.
Claim 41
Dependent Claim
17 words
The composition of claim 36 wherein each A - is Cl - and x is about 14.
Claim 42
Dependent Claim
18 words
The composition of claim 29 wherein said quaternary ammonium polymer is poly (oxyethylene (dimethyliminio) ethylene dimethyliminio) ethylene dichloride.
References Cited (Backward Citations)
US3771989A
Cited
US3910296B1
Cited
US3910296A
Cited
US3912451A
Cited
US4029817A
Cited
US4168112A
Cited
US4304894A
Cited
US4250269A
Cited
US4443429A
Cited
US4499077A
Cited
US4532128A
Cited
US4525346A
Cited
US4615882A
Cited
US4654208A
Cited
GB2139260A
Cited
US4568517A
Cited
US4836986A
Cited
USRE32672E
Cited
US4786436A
Cited
JPS63131124A
Cited
US4783488A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-09-08 | 1996-03-09 | 1996-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-09-08 | 2000-03-09 | 2000-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-09-08 | 2004-03-09 | 2004-09-08 | $7700.00 | Window Closed / Lapsed |