Patent US5232708A successfully refreshed from Google Patents.
US5232708A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coated veterinary implants
Assignee: Monsanto Technology LLC
•
Filing: 1992-05-21
•
Granted: 1993-08-03
•
Expires: 2012-05-21
Abstract
Abstract Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering of from about 3 to 25 ug PVA/mm2 surface area of pellet.
Inventors
- 👤 Ernesto J. Castillo
- 👤 Kenneth E. Eigenberg
- 👤 Kanaiyalal R. Patel
- 👤 Milton J. Sabacky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
70 words
A method of extending the release characteristics of an implantable solid dosage form of a growth hormone for parentally administering to an animal which comprises coating said entire dosage form with a release inhibiting coating of polyvinyl alcohol having a molecular weight of at least about 10,000, a degree of hydrolysis of at least about 95%, said coating comprising form about 0.5 to 5% by weight of the coated product.
Claim 2
Independent Claim
70 words
A method of extending the release characteristics of an implantable solid dosage form of a growth hormone for parentally administering to an animal which comprises coating said entire dosage form with a release inhibiting coating of polyvinyl alcohol having a molecular weight of at least about 10,000, a degree of hydrolysis of at least about 95%, said coating comprising form about 0.5 to 5% by weight of the coated product.
Claim 3
Dependent Claim
21 words
The process of claim 1 wherein the coating is applied in an amount of from 3 to 25 μg/mm 2 .
Claim 4
Dependent Claim
19 words
The process of claim 1 wherein said polyvinyl alcohol has a molecular weight of from about 20,000 to 100,000.
Claim 5
Dependent Claim
19 words
The process of claim 2 wherein said polyvinyl alcohol has a molecular weight of from about 20,000 to 100,000.
Claim 6
Dependent Claim
19 words
The process of claim 1 wherein said polyvinyl alcohol has a degree of hydrolysis of at least about 98%.
Claim 7
Dependent Claim
19 words
The process of claim 2 wherein said polyvinyl alcohol has a degree of hydrolysis of at least about 98%.
Claim 8
Dependent Claim
19 words
The process of claim 3 wherein said polyvinyl alcohol has a degree of hydrolysis of at least about 98%.
References Cited (Backward Citations)
US4808353A
Cited
US4645755A
Cited
US4849359A
Cited
US4720384A
Cited
US4895724A
Cited
US4786501A
Cited
US4863736A
Cited
US5047244A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-08-02 | 1997-02-01 | 1997-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-08-02 | 2001-02-01 | 2001-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-08-02 | 2005-02-01 | 2005-08-03 | $7700.00 | Window Closed / Lapsed |