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US5498549A
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Sensors and methods for sensing
Assignee: Terumo Cardiovascular Systems Corp
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Filing: 1995-01-18
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Granted: 1996-03-12
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Expires: 2015-01-18
Abstract
Abstract A sensor for measuring the concentration of an analyte in a medium is disclosed. In one embodiment, the sensor comprises a sensing element including a matrix material and, covalently bonded thereto, one or more monomeric indicator components each of which is capable of providing a first emitted signal of a given wavelength in response to being exposed to an excitation signal. The sensing element is capable of providing a second emitted signal having a longer wavelength than the first emitted signal or signals in response to being exposed to the excitation signal, the second emitted signal being provided by an excimer component produced in the sensing element from the monomeric indicator component(s) and being dependent on the concentration of the analyte in the medium to a greater extent than the first emitted signal or signals. In another embodiment, the sensor comprises a sensing element including two or more different monomeric components at least one or which is a monomeric indicator component capable of providing a first emitted signal in response to being exposed to a first excitation signal. The sensing element is capable of providing a second emitted signal in response to being exposed to a second excitation signal. This second emitted signal is provided by an exciplex produced from the monomeric components. This second emitted signal is preferably dependent on the concentration of the analyte in the medium. An excitation assembly is positioned and adapted to provide the excitation signal to the sensing element. A detector assembly is positioned and adapted to detect the second emitted signal. Preferably, a processor assembly is positioned and adapted to analyze the second emitted signal in determining the concentration of the analyte in the medium.
Inventors
- 👤 Colleen C. Nagel
- 👤 James G. Bentsen
- 👤 Masao Yafuso
- 👤 Alan R. Katritzky
- 👤 John L. Dektar
- 👤 Cary A. Kipke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 11:54
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/1459; C; C07; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/0834; C07F7/0838; C08; C08G; C08G77/00; C08G77/04; C08G77/38; G01N21/62; G01N21/63; G01N21/64; G01N21/6428; G01N31/00; G01N31/22; G01N31/223; G01N31/225; G01N2021/6434; G01N2021/7706; G01N2021/772; G01N2021/773; G01N2021/7769; G01N2021/7786; Y; Y10; Y10S; Y10S436/00; Y10S436/80; Y10S436/805; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
155 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and an indicator component in said matrix material comprising at least two monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal which is dependent on the concentration of said analyte in said medium; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said second emitted signal in determining the concentration of said analyte in said medium.
Claim 2
Independent Claim
155 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and an indicator component in said matrix material comprising at least two monomeric components in enforced association, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal which is dependent on the concentration of said analyte in said medium; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said second emitted signal in determining the concentration of said analyte in said medium.
Claim 3
Dependent Claim
47 words
The method of claim 1, wherein said analyzing step includes determining an intensity ratio of said second emitted signal to said first emitted signal or at least one of said first emitted signals, said intensity ratio being dependent on the concentration of said analyte in said medium.
Claim 4
Dependent Claim
221 words
The method of claim 1, wherein said first emitted signal or at least one of said first emitted signals and said second emitted signal are modulated, and at least one of: an extent of a phase shift between a modulated second excitation signal and said modulated second emitted signal; or an extent of a phase shift between said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or an extent of a phase shift between a combined modulated first and second emitted signals and said first excitation signal or signals; or a magnitude of relative demodulation between said modulated second excitation signal and said modulated second emitted signal; or a ratio of demodulation factors of said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or a magnitude of relative demodulation between a combined modulated first emitted signal or signals and the modulated second emitted signal; or a excitation frequency necessary to maintain a fixed phase shift between said modulated first and second emitted signals is dependent on the concentration of said analyte in said medium and wherein a processor assembly is adapted to determine at least one of said phase shift, said demodulation factor, or said excitation frequency.
Claim 5
Independent Claim
165 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an exciplex component produced from said at least two monomeric components, said exciplex component providing a second emitted signal which is dependent on the concentration of said analyte in said medium wherein at least one of said monomeric components is covalently bonded to said matrix material; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium.
Claim 6
Independent Claim
165 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an exciplex component produced from said at least two monomeric components, said exciplex component providing a second emitted signal which is dependent on the concentration of said analyte in said medium wherein at least one of said monomeric components is covalently bonded to said matrix material; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium.
Claim 7
Dependent Claim
47 words
The method of claim 4, wherein said analyzing step includes determining an intensity ratio of said second emitted signal to said first emitted signal or at least one of said first emitted signals, said intensity ratio being dependent on the concentration of said analyte in said medium.
Claim 8
Dependent Claim
221 words
The method of claim 4, wherein said first emitted signal or at least one of said first emitted signals and said second emitted signal are modulated, and at least one of: an extent of a phase shift between a modulated second excitation signal and said modulated second emitted signal; or an extent of a phase shift between said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or an extent of a phase shift between a combined modulated first and second emitted signals and said first excitation signal or signals; or a magnitude of relative demodulation between said modulated second excitation signal and said modulated second emitted signal; or a ratio of demodulation factors of said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or a magnitude of relative demodulation between a combined modulated first emitted signal or signals and the modulated second emitted signal; or an excitation frequency necessary to maintain a fixed phase shift between said modulated first and second emitted signals is dependent on the concentration of said analyte in said medium and wherein a processor assembly is adapted to determine at least one of said phase shift, said demodulation factor, or said excitation frequency.
Claim 9
Independent Claim
174 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an exciplex component produced from said at least two monomeric components, said exciplex component providing a second emitted signal which is dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the second emitted signal has less than ten percent contribution due to monomer emission; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium.
Claim 10
Independent Claim
174 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and at least two different monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an exciplex component produced from said at least two monomeric components, said exciplex component providing a second emitted signal which is dependent on the concentration of said analyte in said medium, and wherein a total integrated intensity at the wavelength of the second emitted signal has less than ten percent contribution due to monomer emission; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium.
Claim 11
Dependent Claim
47 words
The method of claim 7, wherein said analyzing step includes determining an intensity ratio of said second emitted signal to said first emitted signal or at least one of said first emitted signals, said intensity ratio being dependent on the concentration of said analyte in said medium.
Claim 12
Dependent Claim
221 words
The method of claim 7, wherein said first emitted signal or at least one of said first emitted signals and said second emitted signal are modulated, and at least one of: an extent of a phase shift between a modulated second excitation signal and said modulated second emitted signal; or an extent of a phase shift between said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or an extent of a phase shift between a combined modulated first and second emitted signals and said first excitation signal or signals; or a magnitude of relative demodulation between said modulated second excitation signal and said modulated second emitted signal; or a ratio of demodulation factors of said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or a magnitude of relative demodulation between a combined modulated first emitted signal or signals and the modulated second emitted signal; or an excitation frequency necessary to maintain a fixed phase shift between said modulated first and second emitted signals is dependent on the concentration of said analyte in said medium and wherein a processor assembly is adapted to determine at least one of said phase shift, said demodulation factor, or said excitation frequency.
Claim 13
Independent Claim
175 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and at least two monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal having a longer wavelength than said first emitted signal and being dependent on the concentration of said analyte in said medium wherein at least one of said monomeric components is covalently bonded to said matrix material; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium.
Claim 14
Independent Claim
175 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising an analyte permeable matrix material and at least two monomeric components at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal having a longer wavelength than said first emitted signal and being dependent on the concentration of said analyte in said medium wherein at least one of said monomeric components is covalently bonded to said matrix material; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium.
Claim 15
Dependent Claim
47 words
The method of claim 10, wherein said analyzing step includes determining an intensity ratio of said second emitted signal to said first emitted signal or at least one of said first emitted signals, said intensity ratio being dependent on the concentration of said analyte in said medium.
Claim 16
Dependent Claim
221 words
The method of claim 10, wherein said first emitted signal or at least one of said first emitted signals and said second emitted signal are modulated, and at least one of: an extent of a phase shift between a modulated second excitation signal and said modulated second emitted signal; or an extent of a phase shift between said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or an extent of a phase shift between a combined modulated first and second emitted signals and said first excitation signal or signals; or a magnitude of relative demodulation between said modulated second excitation signal and said modulated second emitted signal; or a ratio of demodulation factors of said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or a magnitude of relative demodulation between a combined modulated first emitted signal or signals and the modulated second emitted signal; or an excitation frequency necessary to maintain a fixed phase shift between said modulated first and second emitted signals is dependent on the concentration of said analyte in said medium and wherein a processor assembly is adapted to determine at least one of said phase shift, said demodulation factor, or said excitation frequency.
Claim 17
Independent Claim
349 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising at least two monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium, wherein said first emitted signal or at least one of said first emitted signals and said second emitted signal are modulated, and at least one of: an extent of a phase shift between a modulated second excitation signal and said modulated second emitted signal; or an extent of a phase shift between said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or an extent of a phase shift between a combined modulated first and second emitted signals and said first excitation signal or signals; or a magnitude of relative demodulation between said modulated second excitation signal and said modulated second emitted signal; or a ratio of demodulation factors of said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or a magnitude of relative demodulation between a combined modulated first emitted signal or signals and the modulated second emitted signal; or an excitation frequency necessary to maintain a fixed phase shift between said modulated first and second emitted signals is dependent on the concentration of said analyte in said medium and wherein a processor assembly is adapted to determine at least one of said phase shift, said demodulation factor, or said excitation frequency.
Claim 18
Independent Claim
349 words
A method for sensing the concentration of an analyte in a medium comprising the steps of: exposing a sensing element to said medium, said sensing element comprising at least two monomeric components, at least one of which is a monomeric indicator component which provides a first emitted signal or signals in response to being exposed to a first excitation signal, said sensing element further comprising, when exposed to said first excitation signal, an excited state complex produced from said at least two monomeric components, said excited state complex providing a second emitted signal; causing said sensing element to provide said first emitted signal or signals and said second emitted signal; and analyzing said first emitted signal or signals and said second emitted signal in determining the concentration of said analyte in said medium, wherein said first emitted signal or at least one of said first emitted signals and said second emitted signal are modulated, and at least one of: an extent of a phase shift between a modulated second excitation signal and said modulated second emitted signal; or an extent of a phase shift between said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or an extent of a phase shift between a combined modulated first and second emitted signals and said first excitation signal or signals; or a magnitude of relative demodulation between said modulated second excitation signal and said modulated second emitted signal; or a ratio of demodulation factors of said modulated first emitted signal or at least one of said modulated first emitted signals and said modulated second emitted signal; or a magnitude of relative demodulation between a combined modulated first emitted signal or signals and the modulated second emitted signal; or an excitation frequency necessary to maintain a fixed phase shift between said modulated first and second emitted signals is dependent on the concentration of said analyte in said medium and wherein a processor assembly is adapted to determine at least one of said phase shift, said demodulation factor, or said excitation frequency.
Claim 19
Dependent Claim
13 words
The method of claim 13, wherein said monomeric components are covalently bonded together.
Claim 20
Dependent Claim
16 words
The method of claim 1, wherein said at least two monomeric components are covalently bonded together.
Claim 21
Dependent Claim
24 words
The method of claim 1, wherein said at least two monomeric components are different and said produced excited state complex is an exciplex component.
Claim 22
Dependent Claim
17 words
The method of claim 1, wherein said indicator component is covalently bonded to said solid matrix material.
Claim 23
Dependent Claim
92 words
The method of claim 1, wherein said monomeric components in enforced association are selected from the group consisting of intramolecular excited state complex forming molecules dispersed in a matrix material, intramolecular excited state complex forming molecules covalently attached, adsorbed or otherwise attached to the surface of a matrix material, intramolecular excited state complex forming molecules covalently attached to a matrix material, monomeric component aggregates covalently attached to a matrix material, monomeric component aggregates adsorbed to the surface of a matrix material, an inclusion complex comprising a supra-molecule, and ionically bound monomeric components.
Claim 24
Dependent Claim
20 words
The method of claim 4, wherein at least two of said monomeric components are covalently bonded to said matrix material.
Claim 25
Dependent Claim
17 words
The method of claim 4, wherein said at least two different monomeric components are covalently bonded together.
Claim 26
Dependent Claim
20 words
The method of claim 7, wherein said at least two different monomeric components are linked by less than 20 atoms.
Claim 27
Dependent Claim
21 words
The method of claim 10, wherein said at least two monomeric components are covalently bonded together or to said matrix material.
Claim 28
Dependent Claim
24 words
The method of claim 10, wherein said at least two monomeric components are different and said produced excited state complex is an exciplex component.
Claim 29
Dependent Claim
16 words
The method of claim 13, wherein said at least two monomeric components are covalently bonded together.
Claim 30
Dependent Claim
24 words
The method of claim 13, wherein said at least two monomeric components are different and said produced excited state complex is an exciplex component.
Claim 31
Dependent Claim
21 words
The method of claim 1, wherein said analyte comprises oxygen, said medium comprises blood, and said matrix comprises a silicone material.
Claim 32
Dependent Claim
14 words
The method of claim 1, wherein said indicator component comprises a polynuclear aromatic compound.
Claim 33
Dependent Claim
34 words
The method of claim 1, wherein said indicator component comprises a polynuclear aromatic compound selected from the group consisting of perylene, decacyclene, benzoperylene, coronene, pyrene, porphycine, porphyrin, chlorin, phthalocyanine and derivatives and mixtures thereof.
Claim 34
Dependent Claim
86 words
The method of claim 7, wherein said exciplex component comprises at least one polynuclear aromatic monomeric component selected from the group consisting of biphenyl, naphthalene, phenanthrene, p-terphenyl, chrysene, benzpyrene, pyrene, dibenzanthrene, benzanthrene, anthracene, perylene, benzperylene, fluoranthene, coronene, quinoline, phenylquinoline, benzquinoline, quinoxaline, dibenzquinoxaline, benzquinoxaline, phthalimide, pyridine, phenazine, dibenzphenzine, acridine, benzacridine and derivatives of these compounds and at least one monomeric component selected from the group consisting of tetramethyl-p-phenylenediamine, dimethoxydimethylaniline, methoxydimethylaniline, diethylaniline, diphenylmethylamine, triethylamine, indole, dimethyltoluidine, tri-p-anisylamine, ditolylmethylamine, tritolylamine, triphenylamine, ethylcarbazole, trimethoxybenzene, tetramethoxybenzene and derivatives of these compounds.
Claim 35
Dependent Claim
30 words
The method of claim 7, wherein said exciplex component comprises at least one polynuclear aromatic monomeric component and at least one aliphatic or aromatic amine-containing or aromatic ether-containing monomeric component.
Claim 36
Dependent Claim
42 words
The method of claim 7, wherein said exciplex component comprises at least one aromatic nitrite monomeric component and at least one monomeric component selected from the group consisting of polynuclear aromatic monomeric components, aliphatic or aromatic amine-containing or aromatic ether-containing monomeric components.
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