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US5507723A
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Method and system for optimizing dialysis clearance
Assignee: Baxter International Inc
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Filing: 1994-05-24
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Granted: 1996-04-16
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Expires: 2014-05-24
Abstract
Abstract A system and method using same are provided for determining the optimum operating conditions of a dialysis process that yields the highest whole body dialysis clearance. The system varies a parameter that effects dialysis efficiency during part of a dialysis run. The system then measures a metabolite concentration in an outflow dialysate. The system develops a metabolite concentration profile as a function of the varied parameter. Based on these measurements, the system correlates the metabolite concentration measurements to determine the optimum parameter setting that yields the maximum metabolite concentration.
Inventors
- 👤 Prakash R. Keshaviah
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:21
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1601; A61M1/1603; A61M1/1605; A61M1/1609; A61M1/1613; A61M1/1615; A61M1/1617; A61M2202/00; A61M2202/04; A61M2202/0496; A61M2202/0498; A61M2205/00; A61M2205/15
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
74 words
A method for obtaining the highest whole body dialysis clearance in a dialysis system comprising the steps of: varying a parameter that effects dialysis efficiency during part of a dialysis run; measuring a metabolite concentration in an outflow dialysate; developing a metabolite concentration profile as a function of the varied parameter from the metabolite concentration measurements; and correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration.
Claim 2
Independent Claim
74 words
A method for obtaining the highest whole body dialysis clearance in a dialysis system comprising the steps of: varying a parameter that effects dialysis efficiency during part of a dialysis run; measuring a metabolite concentration in an outflow dialysate; developing a metabolite concentration profile as a function of the varied parameter from the metabolite concentration measurements; and correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein the parameter is blood flow rate.
Claim 4
Dependent Claim
16 words
The method of claim 2 further comprising stepwise increasing the blood flow rate in specified increments.
Claim 5
Dependent Claim
16 words
The method of claim 2 further comprising stepwise decreasing the blood flow rate in specified decrements.
Claim 6
Dependent Claim
22 words
The method of claim 2 further comprising the step of storing an optimum blood flow rate associated with the maximum metabolite concentration.
Claim 7
Dependent Claim
21 words
The method of claim 1 wherein the metabolite is selected from the group consisting of: urea, creatinine, phosphate, and uric acid.
Claim 8
Dependent Claim
17 words
The method of claim 1 further comprising measuring the metabolite concentration each time the parameter is varied.
Claim 9
Independent Claim
75 words
A method for determining the optimum blood pump setting of a dialysis system to obtain the highest whole body dialysis clearance comprising the steps of: varying a blood flow rate during a dialysis run; measuring a metabolite concentration in an outflow dialysate; developing a metabolite concentration profile as a function of the blood flow rate; and correlating the metabolite concentration measurements to determine an optimum blood flow rate setting that yields a maximum metabolite concentration.
Claim 10
Independent Claim
75 words
A method for determining the optimum blood pump setting of a dialysis system to obtain the highest whole body dialysis clearance comprising the steps of: varying a blood flow rate during a dialysis run; measuring a metabolite concentration in an outflow dialysate; developing a metabolite concentration profile as a function of the blood flow rate; and correlating the metabolite concentration measurements to determine an optimum blood flow rate setting that yields a maximum metabolite concentration.
Claim 11
Dependent Claim
21 words
The method of claim 8 wherein the metabolite is selected from the group consisting of: urea, creatinine, phosphate, and uric acid.
Claim 12
Dependent Claim
16 words
The method of claim 8 further comprising stepwise increasing the blood flow rate in specified increments.
Claim 13
Dependent Claim
16 words
The method of claim 8 further comprising stepwise decreasing the blood flow rate in specified decrements.
Claim 14
Dependent Claim
18 words
The method of claim 8 further comprising measuring the metabolite concentration each time the blood flow is varied.
Claim 15
Dependent Claim
22 words
The method of claim 8 further comprising the step of storing an optimum blood flow rate associated with the maximum metabolite concentration.
Claim 16
Independent Claim
74 words
A system for obtaining the highest whole body dialysis clearance in a dialysis system comprising: means for varying a parameter that effects dialysis efficiency during part of a dialysis run; means for measuring a metabolite concentration in an outflow dialysate; means for developing a metabolite concentration profile as a function of the varied parameter; and means for correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration.
Claim 17
Independent Claim
74 words
A system for obtaining the highest whole body dialysis clearance in a dialysis system comprising: means for varying a parameter that effects dialysis efficiency during part of a dialysis run; means for measuring a metabolite concentration in an outflow dialysate; means for developing a metabolite concentration profile as a function of the varied parameter; and means for correlating the metabolite concentration measurements to determine an optimum parameter setting that yields a maximum metabolite concentration.
Claim 18
Dependent Claim
12 words
The system of claim 14 wherein the parameter is blood flow rate.
Claim 19
Dependent Claim
17 words
The system of claim 15 further comprising means for increasing the blood flow rate in specified increments.
Claim 20
Dependent Claim
17 words
The system of claim 15 further comprising means for decreasing the blood flow rate in specified decrements.
Claim 21
Dependent Claim
21 words
The system of claim 14 wherein the metabolite is selected from the group consisting of: urea, creatinine, phosphate, and uric acid.
Claim 22
Dependent Claim
20 words
The system of claim 14 further comprising means for storing an optimum parameter setting associated with the maximum metabolite concentration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-16 | 1999-10-16 | 2000-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-16 | 2003-10-16 | 2004-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-16 | 2007-10-16 | 2008-04-16 | $7700.00 | Window Closed / Lapsed |