Patent US5534241A successfully refreshed from Google Patents.
US5534241A
Expired / Lapsed
US
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Amphipathic polychelating compounds and methods of use
Assignee: Individual
•
Filing: 1993-07-23
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Granted: 1996-07-09
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Expires: 2013-07-23
Abstract
Abstract An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the polymeric moiety, and a plurality of chelating agents linked to the side groups of the polymeric moiety. The polychelating compounds are bound to liposomes or micelles for use as diagnostic and therapeutic agents.
Inventors
- 👤 Vladimir P. Torchilin
- 👤 Vladimir S. Trubetskoy
- 👤 Gerald L. Wolf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 17:23
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/1812; A61K51/00; A61K51/12; A61K51/1217; A61K51/1227; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
64 words
A micelle comprising lipids and an amphipathic polychelating compound comprising a hydrophilic polymeric moiety having a backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of said polymeric moiety, and a plurality of chelating agents linked to the side groups of said polymeric moiety, wherein said polychelating compound is linked to said lipids via said lipid-soluble anchor.
Claim 2
Dependent Claim
64 words
A micelle comprising lipids and an amphipathic polychelating compound comprising a hydrophilic polymeric moiety having a backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of said polymeric moiety, and a plurality of chelating agents linked to the side groups of said polymeric moiety, wherein said polychelating compound is linked to said lipids via said lipid-soluble anchor.
Claim 3
Dependent Claim
66 words
A liposome comprising a lipid bilayer membrane and an amphipathic polychelating compound comprising hydrophilic polymeric moiety having a backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of said polymeric moiety, and a plurality of chelating agents linked to the side groups of said polymeric moiety, wherein said polychelating compound is bound to said membrane via said lipid-soluble anchor.
Claim 4
Dependent Claim
66 words
A liposome comprising a lipid bilayer membrane and an amphipathic polychelating compound comprising hydrophilic polymeric moiety having a backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of said polymeric moiety, and a plurality of chelating agents linked to the side groups of said polymeric moiety, wherein said polychelating compound is bound to said membrane via said lipid-soluble anchor.
Claim 5
Dependent Claim
21 words
The liposome of claim 2, further comprising a plurality of ions, each ion being bound to one of said chelating agents.
Claim 6
Dependent Claim
14 words
The liposome of claim 2, further comprising a targeting group bound to said membrane.
Claim 7
Dependent Claim
12 words
The liposome of claim 4, wherein said targeting group is an antibody.
Claim 8
Dependent Claim
14 words
The liposome of claim 2, further comprising a protective polymer bound to said membrane.
Claim 9
Dependent Claim
34 words
The liposome of claim 6, wherein said protective polymer is water-soluble, has a chain length longer than that of said hydrophilic polymeric moiety, and has a molecular weight of from 500 to 40,000 daltons.
Claim 10
Dependent Claim
40 words
The liposome of claim 7, wherein said protective polymer is a derivative of a polyethylene glycol (PEG), polypropylene glycol (PPG), polyacrylamide, poly N-vinyl pyrrolidone, polyacrylic acid, polyalcohol, ganglioside, polyamino acid, polysaccharide, polyamidoamine, polyethyleneamine, or a copolymer or block copolymer thereof.
Claim 11
Dependent Claim
14 words
The liposome of claim 4, further comprising a protective polymer bound to said membrane.
Claim 12
Dependent Claim
53 words
A reagent kit comprising lipids and an amphipathic polychelating compound comprising a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of said polymeric moiety, and a plurality of chelating agents linked to the side groups of said polymeric moiety.
Claim 13
Dependent Claim
53 words
A reagent kit comprising lipids and an amphipathic polychelating compound comprising a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of said polymeric moiety, and a plurality of chelating agents linked to the side groups of said polymeric moiety.
Claim 14
Dependent Claim
15 words
The reagent kit of claim 10, further comprising a protective polymer comprising a lipid-soluble anchor.
Claim 15
Dependent Claim
11 words
The reagent kit of claim 10, further comprising a targeting group.
Claim 16
Dependent Claim
16 words
The reagent kit of claim 10, wherein said lipids and said amphipathic polychelating compound are lyophilized.
Claim 17
Dependent Claim
73 words
A method of imaging a target region in the body of a patient, comprising administering a diagnostically effective amount of the liposomes of claim 2 to the patient, said liposomes comprising a plurality of labeling ions linked to said chelating agents on said polychelating compounds, allowing sufficient time for said liposomes to accumulate in the target region, and obtaining an image of the target region by detecting the labeling ions in the region.
Claim 18
Dependent Claim
27 words
The method of claim 14, wherein said liposomes further comprise targeting groups bound to said membranes, said groups effecting accumulation of said liposomes in the target region.
Claim 19
Dependent Claim
16 words
The method of claim 14, wherein said liposomes further comprise protective polymers bound to said membranes.
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