US5587459A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunoconjugates comprising tyrosine kinase inhibitors
Assignee: University of Minnesota System
•
Filing: 1994-08-19
•
Granted: 1996-12-24
•
Expires: 2014-08-19
Abstract
Abstract Immunoconjugates effective for treating cancers and autoimmune diseases in humans are provided which comprise a tyrosine kinase inhibitor linked to a ligand targeting a cell surface receptor which are specifically capable of inhibiting receptor associated tyrosine kinases.
Inventors
- 👤 Fatih M. Uckun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 03:21
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/642; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6835; A61K47/6849; A61P; A61P35/00; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
31 words
An immunoconjugate comprising genistein linked to an anti-CD19 antibody which specifically binds to cell surface CD19 receptor, wherein said immunoconjugate inhibits CD19 associated tyrosine kinase, thereby inducing apoptosis and cell death.
Claim 2
Dependent Claim
31 words
An immunoconjugate comprising genistein linked to an anti-CD19 antibody which specifically binds to cell surface CD19 receptor, wherein said immunoconjugate inhibits CD19 associated tyrosine kinase, thereby inducing apoptosis and cell death.
Claim 3
Dependent Claim
16 words
The immunoconjugate of claim 1, wherein the genistein is linked to the antibody by photaffinity cross-linking.
Claim 4
Dependent Claim
29 words
The immunoconjugate of claim 1, wherein the anti-CD19 antibody is B43 produced by hybridoma cells having ATCC accession number HB 8903 or a CD19 specific antibody derived from B43.
Claim 5
Dependent Claim
18 words
An immunoconjugate comprising genistein linked to an antibody produced by hybridoma cells having ATCC accession number HB 8903.
Claim 6
Dependent Claim
18 words
An immunoconjugate comprising genistein linked to an antibody produced by hybridoma cells having ATCC accession number HB 8903.
References Cited (Backward Citations)
JPS61246124A
Cited
US4841077A
Cited
US4960908A
Cited
US4831117A
Cited
JPH03275625A
Cited
US5331014A
Cited
WO1993023069A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-24 | 2000-06-24 | 2000-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-24 | 2004-06-24 | 2004-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-24 | 2008-06-24 | 2008-12-24 | $7700.00 | Window Closed / Lapsed |