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US5587459A
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Immunoconjugates comprising tyrosine kinase inhibitors
Assignee: University of Minnesota System
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Filing: 1994-08-19
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Granted: 1996-12-24
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Expires: 2014-08-19
Abstract
Abstract Immunoconjugates effective for treating cancers and autoimmune diseases in humans are provided which comprise a tyrosine kinase inhibitor linked to a ligand targeting a cell surface receptor which are specifically capable of inhibiting receptor associated tyrosine kinases.
Inventors
- 👤 Fatih M. Uckun
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:30
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61K47/642; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6835; A61K47/6849; A61P; A61P35/00; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
31 words
An immunoconjugate comprising genistein linked to an anti-CD19 antibody which specifically binds to cell surface CD19 receptor, wherein said immunoconjugate inhibits CD19 associated tyrosine kinase, thereby inducing apoptosis and cell death.
Claim 2
Dependent Claim
31 words
An immunoconjugate comprising genistein linked to an anti-CD19 antibody which specifically binds to cell surface CD19 receptor, wherein said immunoconjugate inhibits CD19 associated tyrosine kinase, thereby inducing apoptosis and cell death.
Claim 3
Dependent Claim
16 words
The immunoconjugate of claim 1, wherein the genistein is linked to the antibody by photaffinity cross-linking.
Claim 4
Dependent Claim
29 words
The immunoconjugate of claim 1, wherein the anti-CD19 antibody is B43 produced by hybridoma cells having ATCC accession number HB 8903 or a CD19 specific antibody derived from B43.
Claim 5
Dependent Claim
18 words
An immunoconjugate comprising genistein linked to an antibody produced by hybridoma cells having ATCC accession number HB 8903.
Claim 6
Dependent Claim
18 words
An immunoconjugate comprising genistein linked to an antibody produced by hybridoma cells having ATCC accession number HB 8903.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-24 | 2000-06-24 | 2000-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-24 | 2004-06-24 | 2004-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-24 | 2008-06-24 | 2008-12-24 | $7700.00 | Window Closed / Lapsed |