US5626876A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Floating system for oral therapy
Assignee: LTS Lohmann Therapie Systeme AG
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Filing: 1993-10-25
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Granted: 1997-05-06
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Expires: 2013-10-25
Abstract
Abstract The invention relates to a floatable, oral, therapeutic system, in which a lengthening of the gastrointestinal residence time of medicaments and a controlled delivery thereof are achieved by systems, which are specifically lighter than the gastric fluid, float on the latter and can only with difficulty reach the lower-lying pylorus, said system using at least one structural element with cavities or voids, such as foams or hollow bodies.
Inventors
- 👤 Walter M uller
- 👤 Edzard Anders
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/0012; A61K9/0053; A61K9/0065
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
122 words
A therapeutic system for the oral administration of a medicament comprising a mixture of particles of the medicament in a therapeutically effective amount and a floatable aid part, wherein the floatable aid is a microporous foam material of a polymer selected from the group consisting of polyethylene, polypropylene, polyamide, polystyrene, polyester, polyacrylate, polytetrafluoroethylene, polyvinylchloride, polyvinylidene chloride, copolymers from the monomers on which said polymers are based and polysiloxane, wherein the floatable aid comprises a microporous foam material having a pore diameter of in the range of between 0.2 and 100 micrometers, wherein the microporous foam material does not contain the medicament within its pores, wherein the system delivers the medicament into gastric juices, and wherein the system floats in the gastric juices.
Claim 2
Dependent Claim
122 words
A therapeutic system for the oral administration of a medicament comprising a mixture of particles of the medicament in a therapeutically effective amount and a floatable aid part, wherein the floatable aid is a microporous foam material of a polymer selected from the group consisting of polyethylene, polypropylene, polyamide, polystyrene, polyester, polyacrylate, polytetrafluoroethylene, polyvinylchloride, polyvinylidene chloride, copolymers from the monomers on which said polymers are based and polysiloxane, wherein the floatable aid comprises a microporous foam material having a pore diameter of in the range of between 0.2 and 100 micrometers, wherein the microporous foam material does not contain the medicament within its pores, wherein the system delivers the medicament into gastric juices, and wherein the system floats in the gastric juices.
Claim 3
Dependent Claim
22 words
A therapeutic system according to claim 1, wherein the medicament is coated with a polymeric substance extrinsic from the microporous foam material.
Claim 4
Dependent Claim
29 words
A therapeutic system according to claim 1, wherein the system is constituted by a mixture consisting essentially of a drug as said medicament mixed with polymeric microporous foam material.
Claim 5
Dependent Claim
24 words
A therapeutic system according to claim 1, wherein the microporous material is distributed through the system by mixture with material forming the medicament part.
Claim 6
Dependent Claim
21 words
A therapeutic system according to claim 1, wherein the system disintegrates when contacting gastric juices into many small elements having micropores.
Claim 7
Dependent Claim
137 words
A therapeutic system for the oral administration of medicament comprising a medicament-containing part having a therapeutically effective amount of the medicament and a floatable aid part having a cavity-containing character, wherein the system delivers the medicament into the gastric juices, wherein the medicament is in physical contact with the floatable aid, wherein the floatable aid is a microporous foam material of a polymer selected from the group consisting of polyethylene, polypropylene, polyamide, polystyrene, polyester, polyacrylate, polytetrafluoroethylene, polyvinylchloride, polyvinylidene chloride, copolymers from the monomers on which said polymers are based and polysiloxane, wherein the floatable aid comprises a microporous foam material having a pore diameter of in the range of between 0.2 and 100 micrometers, wherein the microporous foam material does not contain the medicament within its pores, and wherein the floatable aid floats in the gastric juices.
Claim 8
Dependent Claim
137 words
A therapeutic system for the oral administration of medicament comprising a medicament-containing part having a therapeutically effective amount of the medicament and a floatable aid part having a cavity-containing character, wherein the system delivers the medicament into the gastric juices, wherein the medicament is in physical contact with the floatable aid, wherein the floatable aid is a microporous foam material of a polymer selected from the group consisting of polyethylene, polypropylene, polyamide, polystyrene, polyester, polyacrylate, polytetrafluoroethylene, polyvinylchloride, polyvinylidene chloride, copolymers from the monomers on which said polymers are based and polysiloxane, wherein the floatable aid comprises a microporous foam material having a pore diameter of in the range of between 0.2 and 100 micrometers, wherein the microporous foam material does not contain the medicament within its pores, and wherein the floatable aid floats in the gastric juices.
Claim 9
Dependent Claim
20 words
The therapeutic system according to claim 6, wherein the medicament-containing part forms a hydrogel when in contact with gastric juices.
Claim 10
Dependent Claim
25 words
The therapeutic system according to claim 6, wherein the system is provided with a coating of the system for the controlled delivery of the medicament.
Claim 11
Dependent Claim
17 words
The therapeutic system according to claim 6, wherein the system is in the form of a tablet.
Claim 12
Dependent Claim
17 words
The therapeutic system according to claim 6, wherein the system is in the form of a foil.
Claim 13
Dependent Claim
15 words
A therapeutic system according to claim 6, wherein the medicament-containing part is a shaped body.
Claim 14
Dependent Claim
14 words
A therapeutic system according to claim 6, wherein the medicament-containing part is an extrudate.
Claim 15
Dependent Claim
16 words
A therapeutic system according to claim 6, wherein the medicament-containing part is a hot melt material.
Claim 16
Dependent Claim
16 words
The therapeutic system according to claim 6, wherein the floatable aid is formed of hollow elements.
Claim 17
Dependent Claim
14 words
The therapeutic system according to claim 6, wherein the floatable aid is an extrudate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-05-05 | 2000-11-04 | 2001-05-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-05-05 | 2004-11-04 | 2005-05-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-05-05 | 2008-11-04 | 2009-05-06 | $7700.00 | Window Closed / Lapsed |