US6071491A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Detection of necrotic malignant tissue and associated therapy
Assignee: MIDCAP FUNDING III LLC
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Filing: 1999-08-09
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Granted: 2000-06-06
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Expires: 2019-08-09
Abstract
Abstract Disclosed are methods for identifying the presence of a tumor in a mammal, comprising the steps of obtaining an antibody against cell ghosts, wherein the antibody is specific to an intracellular antigen not present on the cell surface of normal or neoplastic cells, and wherein the antibody is labeled with a label capable of being imaged; administering the antibody to the mammal, thereby permitting the antibody to bind preferentially to necrotic tissue; and imaging the binding of the antibody to the necrotic tissue, wherein a localized concentration of said antibody is indicative of the presence of a tumor. The antibodies used in these methods are preferably monoclonal antibodies, are also preferably specific for one or more nuclear proteins, and are also preferably labeled with one or more radionuclides. Also disclosed are antibodies for use with the foregoing methods.
Inventors
- 👤 Alan L. Epstein
- 👤 Clive R. Taylor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 09:50
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/575; G01N33/5758; G01N33/57595; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6835; A61K47/6851; A61K49/00; A61K49/04; A61K49/06; A61K49/08; A61K49/10; A61K49/14; A61K49/16; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1018; A61K51/1045; C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3061; A61K2121/00; A61K2123/00; A61K38/00; C07K2317/00; C07K2317/50; C07K2317/54
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
94 words
A method for identifying the presence of a tumor in a mammal, comprising the steps of: obtaining an antibody against cell ghosts, said antibody being specific to an intracellular antigen not present on the cell surface of normal or neoplastic cells, and said antibody being labeled with a label capable of being imaged; administering said antibody to said mammal, thereby permitting said antibody to bind to necrotic tissue; and imaging the binding of said antibody to said necrotic tissue, wherein a localized concentration of said antibody is indicative of the presence of a tumor.
Claim 2
Independent Claim
94 words
A method for identifying the presence of a tumor in a mammal, comprising the steps of: obtaining an antibody against cell ghosts, said antibody being specific to an intracellular antigen not present on the cell surface of normal or neoplastic cells, and said antibody being labeled with a label capable of being imaged; administering said antibody to said mammal, thereby permitting said antibody to bind to necrotic tissue; and imaging the binding of said antibody to said necrotic tissue, wherein a localized concentration of said antibody is indicative of the presence of a tumor.
Claim 3
Dependent Claim
31 words
The method of claim 1, wherein the step of obtaining an antibody comprises obtaining an antibody specific for a nuclear protein not present on the surface of normal or neoplastic cells.
Claim 4
Dependent Claim
23 words
The method of claim 1, wherein the step of obtaining an antibody comprises obtaining an antibody that is labeled with a radiopaque material.
Claim 5
Dependent Claim
22 words
The method of claim 1, wherein the step of obtaining an antibody comprises obtaining an antibody that is labeled with a radionuclide.
Claim 6
Dependent Claim
36 words
The method of claim 4, wherein obtaining an antibody that is labeled with a radionuclide comprises obtaining an antibody labeled with a radionuclide selected from the group consisting of: Tc-99m, I-123, 1-125, In-111, In-113m and Ga-67.
Claim 7
Dependent Claim
17 words
The method of claim 1, wherein the step of obtaining an antibody comprises obtaining a monoclonal antibody.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2003-06-06 | 2003-12-06 | 2004-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-06 | 2007-12-06 | 2008-06-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-06 | 2011-12-06 | 2012-06-06 | $7700.00 | Window Closed / Lapsed |