Patent US6080429A successfully refreshed from Google Patents.
US6080429A
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Method for drying microspheres
Assignee: Genentech Inc
•
Filing: 1997-11-07
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Granted: 2000-06-27
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Expires: 2017-11-07
Abstract
Abstract A method for drying microspheres in a fluidized bed is provided, along with a composition comprising microspheres dried by that method.
Inventors
- 👤 Jeffrey L. Cleland
- 👤 Andrew J. S. Jones
- 👤 Michael Frank Powell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 09:08
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/27; A61K39/00; A61K39/12; A61K39/21; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1682; A61K9/1694; A61K2039/555; A61K2039/55511; A61K2039/55555; A61K2039/55566; A61K2039/55577; C; C12; C12N; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/16011; C12N2740/16111; C12N2740/16134
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
115 words
A method for preparing microspheres wherein an active agent is dispersed within a polymer matrix by a water-in-oil or a solid-in-oil process comprising (a) dissolving a polymer in an organic solvent to produce a solution; (b) adding an active agent or an aqueous solution thereof to the solution of step (a) to produce a polymer-active agent solid-in-oil or water-in-oil first emulsion or suspension; (c) extracting the excess organic solvent from the first emulsion or suspension with an aqueous solution to produce microspheres; (d) removing the aqueous solution sufficient to provide a final product with less than 20% residual moisture by drying the microspheres of step (c) in a fluidized bed; and (e) recovering the microspheres.
Claim 2
Independent Claim
115 words
A method for preparing microspheres wherein an active agent is dispersed within a polymer matrix by a water-in-oil or a solid-in-oil process comprising (a) dissolving a polymer in an organic solvent to produce a solution; (b) adding an active agent or an aqueous solution thereof to the solution of step (a) to produce a polymer-active agent solid-in-oil or water-in-oil first emulsion or suspension; (c) extracting the excess organic solvent from the first emulsion or suspension with an aqueous solution to produce microspheres; (d) removing the aqueous solution sufficient to provide a final product with less than 20% residual moisture by drying the microspheres of step (c) in a fluidized bed; and (e) recovering the microspheres.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein the organic solvent is methylene chloride.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the organic solvent is ethyl acetate.
Claim 5
Dependent Claim
20 words
The method of claim 1 wherein the organic solvent is a mixture of ethyl acetate and benzyl alcohol or acetone.
Claim 6
Dependent Claim
15 words
The method of claim 1 wherein the aqueous solution of part (c) contains polyvinyl alcohol.
Claim 7
Dependent Claim
13 words
The method of claim 5 wherein the polyvinyl alcohol solution contains ethyl acetate.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein the active agent is a dry solid.
Claim 9
Dependent Claim
21 words
The method of claim 1 wherein an aqueous solution of an active agent is added to the solution of part (a).
Claim 10
Dependent Claim
12 words
The method of claim 1 wherein the active agent is an antigen.
Claim 11
Dependent Claim
12 words
The method of claim 1 wherein the active agent is an adjuvant.
Claim 12
Dependent Claim
21 words
The method of claim 1 wherein the fluidized bed comprises a system wherein a dry gas is passed across wet microspheres.
Claim 13
Dependent Claim
11 words
The method of claim 1 wherein the polymer is a polyester.
Claim 14
Dependent Claim
10 words
The method of claim 12 wherein the polyester is poly(D-L-lactide-co-glycolide).
Claim 15
Dependent Claim
12 words
The method of claim 1 wherein the active agent is a polypeptide.
Claim 16
Dependent Claim
12 words
The method of claim 14 wherein the polypeptide is human growth hormone.
Claim 17
Dependent Claim
10 words
The method of claim 14 wherein the polypeptide is gp120.
Claim 18
Dependent Claim
15 words
A composition comprising microspheres encapsulating an active agent produced by the process of claim 1.
Claim 19
Dependent Claim
13 words
The composition of claim 17 wherein the active agent is a dry solid.
Claim 20
Dependent Claim
21 words
The composition of claim 17 wherein an aqueous solution of an active agent is added to the solution of part (a).
Claim 21
Dependent Claim
12 words
The composition of claim 17 wherein the active agent is an antigen.
Claim 22
Dependent Claim
12 words
The composition of claim 17 wherein the active agent is an adjuvant.
Claim 23
Dependent Claim
12 words
The composition of claim 17 wherein the active agent is a polypeptide.
Claim 24
Dependent Claim
11 words
The composition of claim 22 wherein the polypeptide is growth hormone.
Claim 25
Dependent Claim
10 words
The composition of claim 22 wherein the polypeptide is gp120.
References Cited (Backward Citations)
US3565559A
Cited
US3737337A
Cited
US4293539A
Cited
US4524067A
Cited
US4389330A
Cited
US4675189A
Cited
US4767628B1
Cited
US4767628A
Cited
US4637905A
Cited
US4652441A
Cited
US4917893A
Cited
US4568559A
Cited
US4954298A
Cited
US4728721A
Cited
US4849228A
Cited
US4962091A
Cited
AU7992987A
Cited
EP0266119A2
Cited
US5075109A
Cited
US4719246A
Cited
EP0279688A2
Cited
US5057540A
Cited
US5198533A
Cited
US4897268A
Cited
US5100669A
Cited
EP0333523A2
Cited
US5068112A
Cited
US4902515A
Cited
WO1990003984A1
Cited
US5008116A
Cited
US4990336A
Cited
EP0442671A2
Cited
WO1991012882A1
Cited
WO1993007861A1
Cited
US5348867A
Cited
US5667808A
Cited
US5624612A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-06-27 | 2003-12-27 | 2004-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-27 | 2007-12-27 | 2008-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-27 | 2011-12-27 | 2012-06-27 | $7700.00 | Window Closed / Lapsed |