Patent US6424847B1 successfully refreshed from Google Patents.
US6424847B1
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US
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Glucose monitor calibration methods
Assignee: Medtronic Minimed Inc
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Filing: 2000-02-23
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Granted: 2002-07-23
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Expires: 2020-02-23
Abstract
Abstract A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.
Inventors
- 👤 John J. Mastrototaro
- 👤 Todd M. Gross
- 👤 John J. Shin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:25
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14532; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723; A61M2005/1726
Claims Analysis
Total Claims: 56
Claim 1
Independent Claim
118 words
A method of calibrating glucose monitor data, the method comprising the steps of: sampling glucose monitor data at a predetermined rate from a glucose sensor over a period of time; deriving at least one glucose monitor data point from the sampled glucose monitor data at a predetermined memory storage rate; obtaining at least one blood glucose reference reading from a blood glucose measuring device that corresponds with the at least one glucose monitor data point; calculating a calibration factor using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration factor post process.
Claim 2
Independent Claim
118 words
A method of calibrating glucose monitor data, the method comprising the steps of: sampling glucose monitor data at a predetermined rate from a glucose sensor over a period of time; deriving at least one glucose monitor data point from the sampled glucose monitor data at a predetermined memory storage rate; obtaining at least one blood glucose reference reading from a blood glucose measuring device that corresponds with the at least one glucose monitor data point; calculating a calibration factor using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration factor post process.
Claim 3
Dependent Claim
31 words
The method of claim 1 , wherein the step of calculating a calibration factor further includes taking account of at least one previous calibration factor to calculate a new calibration factor.
Claim 4
Dependent Claim
50 words
The method of claim 1 , wherein the at least one blood glucose reference reading is at least two blood glucose reference readings and the step of calculating the calibration factor uses the at least two blood glucose reference readings and the corresponding at least one glucose monitor data point.
Claim 5
Dependent Claim
18 words
The method of claim 3 , wherein a calculation of the calibration factor is obtained using linear regression.
Claim 6
Dependent Claim
15 words
The method of claim 4 , wherein the linear regression is least squares linear regression.
Claim 7
Dependent Claim
18 words
The method of claim 1 , wherein a calculation of the calibration factor is obtained using non-linear regression.
Claim 8
Dependent Claim
19 words
The method of claim 1 , wherein a calculation of the calibration factor is obtained using a non-regression technique.
Claim 9
Dependent Claim
17 words
The method of claim 1 , wherein the predetermined memory storage rate is once every 5 minutes.
Claim 10
Dependent Claim
45 words
The method of claim 1 , wherein the glucose monitor data point that is derived at a predetermined memory storage rate is the result of utilizing at least 2 sampled values sampled from the glucose sensor at a rate faster than the memory storage rate.
Claim 11
Dependent Claim
43 words
The method of claim 1 , wherein at least one blood glucose reference reading is obtained during at least one predetermined calibration period, and wherein the calibration factor is calculated using at least one blood glucose reference reading after every predetermined calibration period.
Claim 12
Dependent Claim
17 words
The method of claim 10 , wherein the at least one predetermined calibration period is 24 hours.
Claim 13
Dependent Claim
30 words
The method of claim 1 , wherein one or more calculations for calculating a first calibration factor is different than one or more calculations for calculating all subsequent calibration factors.
Claim 14
Dependent Claim
20 words
The method of claim 12 , wherein the calculation for calculating the first calibration factor uses a single-point calibration equation.
Claim 15
Dependent Claim
15 words
The method of claim 13 , wherein the single-point calibration equation includes an offset value.
Claim 16
Dependent Claim
21 words
The method of claim 13 , wherein the calculation for calculating the subsequent calibration factors uses a linear regression calibration equation.
Claim 17
Dependent Claim
21 words
The method of claim 13 , wherein the calculation for calculating the subsequent calibration factors uses a non-linear regression calibration equation.
Claim 18
Dependent Claim
20 words
The method of claim 13 , wherein the calculation for calculating the subsequent calibration factors uses a non-regression calibration equation.
Claim 19
Dependent Claim
46 words
The method of claim 1 , wherein a predetermined time shift is used to temporally correlate the at least one blood glucose reference reading from a blood glucose measuring device with the at least one glucose monitor data point obtained at the predetermined memory storage rate.
Claim 20
Dependent Claim
14 words
The method of claim 18 , wherein the predetermined time shift is ten minutes.
Claim 21
Dependent Claim
15 words
The method of claim 1 , wherein the calibration factor is a non-linear calibration equation.
Claim 22
Independent Claim
120 words
A method of calibrating glucose monitor data, the method comprising the steps of: sampling glucose monitor data from a sensor; deriving interval values by applying clipping limits and averaging the post-clipped sampled glucose monitor data over a predetermined interval rate; deriving, at least one glucose monitor data point by averaging the derived interval values at a predetermined memory storage rate; obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data point; determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and calibrating the sampled glucose monitor data using the calibration equation.
Claim 23
Independent Claim
120 words
A method of calibrating glucose monitor data, the method comprising the steps of: sampling glucose monitor data from a sensor; deriving interval values by applying clipping limits and averaging the post-clipped sampled glucose monitor data over a predetermined interval rate; deriving, at least one glucose monitor data point by averaging the derived interval values at a predetermined memory storage rate; obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data point; determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and calibrating the sampled glucose monitor data using the calibration equation.
Claim 24
Dependent Claim
32 words
The method of claim 21 , wherein the step of averaging the sampled glucose monitor data over a predetermined interval rate ignores a high and a low sampled value over the interval.
Claim 25
Dependent Claim
40 words
The method of claim 21 , wherein the step of averaging the derived interval values over a predetermined memory storage rate ignores a high and a low derived interval value obtained during one cycle of the predetermined memory storage rate.
Claim 26
Dependent Claim
18 words
The method of claim 21 , wherein the calculation of the calibration equation is obtained using linear regression.
Claim 27
Dependent Claim
16 words
The method of claim 24 , wherein the linear regression is a least squares linear regression.
Claim 28
Dependent Claim
18 words
The method of claim 21 , wherein the calculation of the calibration equation is obtained using non-linear regression.
Claim 29
Dependent Claim
19 words
The method of claim 21 , wherein the calculation of the calibration equation is obtained using a non-regression technique.
Claim 30
Dependent Claim
22 words
The method of claim 21 , wherein the method further comprises the step of shifting the data by a predetermined time factor.
Claim 31
Dependent Claim
17 words
The method of claim 21 , wherein the calibration is performed while sampling the glucose monitor data.
Claim 32
Dependent Claim
31 words
The method of claim 21 , wherein the calibration is performed retrospectively on the sampled glucose monitor data that has been collected for post processing using the calibration equation post process.
Claim 33
Dependent Claim
30 words
The method of claim 21 , wherein one or more calculations for calculating a first calibration factor is different than one or more calculations for calculating all subsequent calibration factors.
Claim 34
Dependent Claim
41 words
The method of claim 31 , wherein the one or more calculations for calculating subsequent calibration factors employ a weighted average using a calibration factor calculated from data collected since the last calibration and previous calibration factors calculated for previous calibrations.
Claim 35
Dependent Claim
20 words
The method of claim 31 , wherein the calculation for calculating a first calibration factor uses a single-point calibration equation.
Claim 36
Dependent Claim
15 words
The method of claim 33 , wherein the single-point calibration equation includes an offset value.
Claim 37
Dependent Claim
21 words
The method of claim 33 , wherein the calculation for calculating the subsequent calibration factors uses a linear regression calibration equation.
Claim 38
Dependent Claim
21 words
The method of claim 33 , wherein the calculation for calculating the subsequent calibration factors uses a non-linear regression calibration equation.
Claim 39
Dependent Claim
20 words
The method of claim 33 , wherein the calculation for calculating the subsequent calibration factors uses a non-regression calibration equation.
Claim 40
Independent Claim
113 words
An apparatus to calibrate glucose monitor data, the apparatus comprising: means for sampling glucose monitor data; means for deriving at least one glucose monitor data reading from the sampled glucose monitor data at a determined memory storage rate, means for obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data reading; means for determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data reading; and means for interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration equation post process.
Claim 41
Independent Claim
113 words
An apparatus to calibrate glucose monitor data, the apparatus comprising: means for sampling glucose monitor data; means for deriving at least one glucose monitor data reading from the sampled glucose monitor data at a determined memory storage rate, means for obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data reading; means for determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data reading; and means for interpreting the sampled glucose monitor data collected during the period of time retrospectively using the calibration equation post process.
Claim 42
Dependent Claim
141 words
An article of manufacture containing code for calibrating glucose monitor data, comprising a computer usable media including at least one embedded computer program that is capable of causing at least one computer to perform: sampling glucose monitor data from a sensor; deriving interval values by applying clipping limits and averaging the post-clipped sampled glucose monitor data over a predetermined interval rate; deriving at least one glucose monitor data point by averaging the derived interval values at a predetermined memory storage rate; obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data point; determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and calibrating the sampled glucose monitor data using the calibration equation.
Claim 43
Dependent Claim
141 words
An article of manufacture containing code for calibrating glucose monitor data, comprising a computer usable media including at least one embedded computer program that is capable of causing at least one computer to perform: sampling glucose monitor data from a sensor; deriving interval values by applying clipping limits and averaging the post-clipped sampled glucose monitor data over a predetermined interval rate; deriving at least one glucose monitor data point by averaging the derived interval values at a predetermined memory storage rate; obtaining from another blood glucose measuring device at least one blood glucose reference reading that is temporally associated with at least one glucose monitor data point; determining a calibration equation using the at least one blood glucose reference reading and the corresponding at least one glucose monitor data point; and calibrating the sampled glucose monitor data using the calibration equation.
Claim 44
Dependent Claim
34 words
The article of manufacture of claim 39 , wherein the step of averaging the sampled glucose monitor data over a predetermined interval rate ignores a high and a low sampled value over the interval.
Claim 45
Dependent Claim
42 words
The article of manufacture of claim 39 , wherein the step of averaging the derived interval values over a predetermined memory storage rate ignores a high and a low derived interval value obtained during one cycle of the predetermined memory storage rate.
Claim 46
Dependent Claim
20 words
The article of manufacture of claim 39 , wherein the calculation of the calibration equation is obtained using linear regression.
Claim 47
Dependent Claim
18 words
The article of manufacture of claim 42 , wherein the linear regression is a least squares linear regression.
Claim 48
Dependent Claim
20 words
The article of manufacture of claim 39 , wherein the calculation of the calibration equation is obtained using non-linear regression.
Claim 49
Dependent Claim
21 words
The article of manufacture of claim 39 , wherein the calculation of the calibration equation is obtained using a non-regression technique.
Claim 50
Dependent Claim
24 words
The article of manufacture of claim 39 , wherein the method further comprises the step of shifting the data by a predetermined time factor.
Claim 51
Dependent Claim
19 words
The article of manufacture of claim 39 , wherein the calibration is performed while sampling the glucose monitor data.
Claim 52
Dependent Claim
33 words
The article of manufacture of claim 39 , wherein the calibration is performed retrospectively on the sampled glucose monitor data that has been collected for post processing using the calibration equation post process.
Claim 53
Independent Claim
113 words
A method of calibrating characteristic monitor data, the method comprising the steps of: sampling characteristic monitor data; deriving interval values by applying clipping limits and averaging the post-clipped sampled characteristic monitor data over a predetermined interval rate; deriving at least one characteristic monitor data point by averaging the derived interval values at a predetermined memory storage rate; obtaining from another characteristic measuring device at least one characteristic reference reading that is temporally associated with at least one characteristic monitor data point; calculating calibration characteristics using the at least one characteristic reference reading and the corresponding at least one characteristic monitor data point; and calibrating the obtained characteristic monitor data using the calibration characteristics.
Claim 54
Independent Claim
113 words
A method of calibrating characteristic monitor data, the method comprising the steps of: sampling characteristic monitor data; deriving interval values by applying clipping limits and averaging the post-clipped sampled characteristic monitor data over a predetermined interval rate; deriving at least one characteristic monitor data point by averaging the derived interval values at a predetermined memory storage rate; obtaining from another characteristic measuring device at least one characteristic reference reading that is temporally associated with at least one characteristic monitor data point; calculating calibration characteristics using the at least one characteristic reference reading and the corresponding at least one characteristic monitor data point; and calibrating the obtained characteristic monitor data using the calibration characteristics.
Claim 55
Dependent Claim
21 words
A method of claim 49 , wherein the at least one characteristic reference reading is at least two characteristic reference readings.
Claim 56
Dependent Claim
19 words
A method of claim 50 , wherein a calculation for calculating the calibration characteristics is a linear regression calculation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-07-22 | 2006-01-21 | 2006-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-07-22 | 2010-01-21 | 2010-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-07-22 | 2014-01-21 | 2014-07-23 | $7700.00 | Window Closed / Lapsed |