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US5474743A
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Cation-sensing composite structure and compounds for use therein
Assignee: Terumo Cardiovascular Systems Corp
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Filing: 1993-10-21
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Granted: 1995-12-12
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Expires: 2013-10-21
Abstract
Abstract A fluorescent ionophoric compound comprises a cryptand portion and a coumarin portion substituted at the 3-position with an electron withdrawing or polarizable group. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures useful in biological and environmental testing, which can be used with conventional glass optics, by means of convenient points of covalent attachment.
Inventors
- 👤 John E. Trend
- 👤 Cary A. Kipke
- 👤 Mitchell A. Rossman
- 👤 Masao Yafuso
- 👤 Sanjay L. Patil
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 14:57
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/12; C07D498/18; C07C; C07C43/00; C07C43/02; C07C43/20; C07C43/23; C07C45/00; C07C45/51; C07C45/511; C07C45/513; C07C45/56; C07C45/57; C07C45/60; C07C47/00; C07C47/52; C07C47/575; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/84
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
65 words
A fluorescent ionophoric compound having the general formula ##STR7## wherein m and n are independently 0 or 1, R is at least one of an electron withdrawing group and a polarizable group, and Z is oxygen or N--R" where R" is H or a C 1 to C 4 alkyl group, said compound having an absorbance maximum in the range of 350 to 440 nm.
Claim 2
Dependent Claim
65 words
A fluorescent ionophoric compound having the general formula ##STR7## wherein m and n are independently 0 or 1, R is at least one of an electron withdrawing group and a polarizable group, and Z is oxygen or N--R" where R" is H or a C 1 to C 4 alkyl group, said compound having an absorbance maximum in the range of 350 to 440 nm.
Claim 3
Dependent Claim
24 words
The ionophoric compound of claim 1 wherein R is selected from the group consisting of carboxyl, carboxamide, sulfonylaryl, ester, keto-alkyl ester, and aromatic groups.
Claim 4
Dependent Claim
12 words
The ionophoric compound of claim 2 wherein R is a carboxyl group.
Claim 5
Dependent Claim
13 words
The ionophoric compound of claim 2 wherein R is an ethyl ester group.
Claim 6
Dependent Claim
15 words
The ionophoric compound of claim 2 wherein said keto-alkyl ester group has the formula ##STR8##
Claim 7
Dependent Claim
30 words
The ionophoric compound of claim 2 wherein said sulfonylaryl or aromatic group is substituted by a group selected from the class consisting of amine, carboxylic acid, and sulfonic acid groups.
Claim 8
Dependent Claim
23 words
The ionophoric compound of claim 2 wherein said aromatic group is selected from the group consisting of phenyl, benzimidazolyl, benzoxazolyl, and benzthiazolyl groups.
Claim 9
Dependent Claim
10 words
The ionophoric compound of claim 1 having the formula ##STR9##
Claim 10
Dependent Claim
80 words
A cation-sensing composite structure comprising a substrate and the fluorescent ionophoric compound of claim 1 wherein said compound is covalently bound to said substrate through R, defined as above, by means of one of a bond and a linking group, said linking group comprising functionalities at both ends, the functionality at one end of said linking group being complementary to the functionality of R and the functionality at the other end being complementary to a functional group on said substrate.
Claim 11
Dependent Claim
43 words
The sensing composite structure according to claim 9 wherein said functionalities of said linking group are independently selected from the group consisting of amine, amide, ester, oxirane, olefin, urea, silanol, carbamate, isocyanate, thioisocyanate, sulfonamide, sulfonyl chloride, carboxyl, chlorotriazine, hydrazine, hydrazide, and aldehyde groups.
Claim 12
Dependent Claim
14 words
The sensing composite structure according to claim 9 wherein said linking group is hydrophilic.
Claim 13
Dependent Claim
20 words
The sensing composite structure according to claim 11 wherein said substrate is selectively permeable to protons or the hydronium ion.
Claim 14
Dependent Claim
17 words
The sensing composite structure according to claim 12 wherein said sensing composite structure is a pH sensor.
Claim 15
Dependent Claim
24 words
The sensing composite structure according to claim 9 wherein said linking group comprises a longest chain including 5 to 125 carbon or hetero atoms.
Claim 16
Dependent Claim
24 words
The sensing composite structure according to claim 14 wherein said longest chain of said linking group comprises 10 to 70 carbon or hetero atoms.
Claim 17
Dependent Claim
13 words
The sensing composite structure according to claim 9 wherein said substrate is hydrophilic.
Claim 18
Dependent Claim
15 words
The sensing composite structure according to claim 9 wherein said substrate comprises a polymeric material.
Claim 19
Dependent Claim
16 words
The sensing composite structure according to claim 17 wherein said polymer is coated on a membrane.
Claim 20
Dependent Claim
77 words
The sensing composite structure according to claim 18 wherein said coated polymer is selected from the group consisting of polyvinylchloride, copolymers and terpolymers of polyvinylchloride, copolymers of styrene and at least one of maleic acid and maleic anhydride, copolymers of polyalkylvinylether and at least one of maleic acid and maleic anhydride, polymers and copolymers of vinyldimethyl azlactone, and copolymers of one of acrylate esters, methacrylate esters, acrylamides, and methacrylamides with one of acrylic acid and methacrylic acid.
Claim 21
Dependent Claim
15 words
The sensing composite structure according to claim 18 wherein said membrane is hydrophilic porous polypropylene.
Claim 22
Dependent Claim
14 words
The sensing composite structure according to claim 17 wherein said polymeric material comprises silica.
Claim 23
Dependent Claim
17 words
The sensing composite structure according to claim 17 wherein said polymeric material possesses a net negative charge.
Claim 24
Dependent Claim
16 words
The sensing composite structure according to claim 9 wherein said substrate is substantially planar in shape.
Claim 25
Dependent Claim
15 words
The sensing composite structure according to claim 9 wherein said composite structure is a powder.
Claim 26
Dependent Claim
20 words
The sensing composite structure according to claim 24 wherein said powder is adhered to a surface which is substantially planar.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-12-11 | 1999-06-12 | 1999-12-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-12-11 | 2003-06-12 | 2003-12-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-12-11 | 2007-06-12 | 2007-12-12 | $7700.00 | Window Closed / Lapsed |