US5932799A
Expired / Lapsed
US
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Microfluidic analyzer module
Assignee: YSI Inc
•
Filing: 1997-07-21
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Granted: 1999-08-03
•
Expires: 2017-07-21
Abstract
Abstract A microfluidic analyzer module. The module is constructed of a plurality of channel forming laminate layers that are directly bonded together without adhesive or other possible contaminant source located proximate the flow channels. The channel forming laminate layers define a network of fluid flow channels. A valve containing layer is directly, adhesivelessly bonded over the channel containing layers. A flexible valve member integral with the valve layer opens and closes communication between feed and sensor channels of the channel network.
Inventors
- 👤 Donald R. Moles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 19:35
CPC Classifications
B; B32; B32B; B32B27/00; B32B27/28; B32B27/281; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01L3/5027; B01L3/502707; B01L3/502738; B32B27/06; B32B27/08; B32B27/34; B32B3/00; B32B3/02; B32B3/08; F; F16; F16K; F16K99/00; F16K99/0001; F16K99/0003; F16K99/0015; F16K99/0034; F16K99/0055; F16K99/0059; B01L2200/00; B01L2200/06; B01L2200/0689; B01L2300/00; B01L2300/08; B01L2300/0887; B01L2400/00; B01L2400/06; B01L2400/0633; B01L2400/0638; B29; B29C; B29C66/00; B29C66/80; B29C66/82; B29C66/826; B29C66/8264; F16K2099/0073; F16K2099/0074; F16K2099/0082; F16K2099/0084; G; G01; G01N; G01N35/00; G01N2035/00178; G01N2035/00237; G01N2035/00247
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
103 words
A microfluidic analyzer module comprising: (a) a first sheet of an adhesiveless self-bondable polyimide having a top surface and a bottom surface; (b) a second sheet of an adhesiveless self-bondable polyimide having a top surface and a bottom surface, said first and second polyimide sheets being in superposed relation with said bottom surface of said first sheet of polyimide facing said top surface of said second sheet of polyimide, said sheets being directly bonded together at the interface of the sheets without an adhesive; and (c) at least one fluid flow channel at the interface of said first sheet and said second sheet.
Claim 2
Dependent Claim
103 words
A microfluidic analyzer module comprising: (a) a first sheet of an adhesiveless self-bondable polyimide having a top surface and a bottom surface; (b) a second sheet of an adhesiveless self-bondable polyimide having a top surface and a bottom surface, said first and second polyimide sheets being in superposed relation with said bottom surface of said first sheet of polyimide facing said top surface of said second sheet of polyimide, said sheets being directly bonded together at the interface of the sheets without an adhesive; and (c) at least one fluid flow channel at the interface of said first sheet and said second sheet.
Claim 3
Dependent Claim
24 words
A microfluidic analyzer module as recited in claim 1 wherein said polyimide of said first sheet and said second sheet contains an organotin compound.
Claim 4
Dependent Claim
72 words
A microfluidic module as recited in claim 1 wherein said flow channels comprise a feed channel and a sensor channel, said module further comprising valve means operatively associated with said feed channel and said sensor channel for selectively opening and closing communication between said feed channel and said sensing channel, and a sensing element disposed in said sensor channel to detect the presence or concentration of an analyte in said sensor channel.
Claim 5
Dependent Claim
138 words
A microfluidic analyzer module as recited in claim 3 wherein said feed channel comprises a feed channel bore extending upwardly through said first sheet of polyimide and terminating in said top surface of said first sheet of polyimide, said sensor channel comprising a sensor channel bore extending upwardly through said first sheet of polyimide and terminating in said top surface of said first sheet of polyimide proximate said feed channel bore, said valve means comprising a flexible material positioned over said feed channel bore and said sensor channel bore, actuation means connected to said valve means for pressing said flexible material over said feed channel bore and said sensor channel bore to block communication therebetween and for relaxing said flexible material in spaced relation over said top surface of said first sheet of polyimide for opening communication therebetween.
Claim 6
Dependent Claim
18 words
A microfluidic analyzer module as recited in claim 4 wherein said sensing element comprises an optical sensing element.
Claim 7
Dependent Claim
18 words
A microfluidic analyzer module as recited in claim 4 wherein said sensing element comprises an electrochemical sensing element.
Claim 8
Dependent Claim
17 words
A microfluidic analyzer module as recited in claim 6 wherein said electrochemical sensing element comprises an electrode.
Claim 9
Dependent Claim
192 words
A laminated microfluidic analyzer module comprising first, second and third layers of polymeric materials, said first and second layers being interfacing layers of adhesiveless self-bondable polyimide polymer which are directly bonded together without adhesive to form a structure having a top surface and a bottom surface, said structure having a fluid flow channel formed at the interface of said layers, said fluid flow channel being in communication with said top surface of said structure, a portion of said top surface being in operative association with said fluid flow channel and constituting a valve region, said third layer of polymeric material superposed over said top surface of said structure overlying said valve region, the portion of said third polymeric material overlying said valve region constituting a valve, said third layer of polymeric material being flexible and being bonded over said top surface of said structure except at said valve region, said third layer of polymeric material retaining its flexibility at said valve region, and a valve actuator operatively associated with said third layer of polymeric material at said valve region for selectively flexing said third layer and thereby closing and opening said valve.
Claim 10
Dependent Claim
192 words
A laminated microfluidic analyzer module comprising first, second and third layers of polymeric materials, said first and second layers being interfacing layers of adhesiveless self-bondable polyimide polymer which are directly bonded together without adhesive to form a structure having a top surface and a bottom surface, said structure having a fluid flow channel formed at the interface of said layers, said fluid flow channel being in communication with said top surface of said structure, a portion of said top surface being in operative association with said fluid flow channel and constituting a valve region, said third layer of polymeric material superposed over said top surface of said structure overlying said valve region, the portion of said third polymeric material overlying said valve region constituting a valve, said third layer of polymeric material being flexible and being bonded over said top surface of said structure except at said valve region, said third layer of polymeric material retaining its flexibility at said valve region, and a valve actuator operatively associated with said third layer of polymeric material at said valve region for selectively flexing said third layer and thereby closing and opening said valve.
Claim 11
Dependent Claim
23 words
A laminated microfluidic analyzer module as recited in claim 8 wherein the polyimide of said first and second layers contains an organotin compound.
Claim 12
Dependent Claim
33 words
Laminated microfluidic analyzer module as recited in claim 8 further including a fourth layer overlying said third layer, said fourth layer comprising a concave surface portion overlying said valve in said third layer.
Claim 13
Dependent Claim
23 words
Laminated microfluidic analyzer module as recited in claim 10 wherein said valve actuator comprises a pressure source communicating with said concave surface portion.
Claim 14
Dependent Claim
66 words
A laminated microfluidic module as recited in claim 8 wherein said module includes a feed channel, a sensor channel, and valve means operatively associated with said feed-channel and said sensor channel for selectively opening and closing communication between said feed channel and said sensor channel, and a sensor disposed in said sensor channel to detect the presence or concentration of an analyte in said sensor channel.
Claim 15
Dependent Claim
139 words
A laminated microfluidic analyzer module as recited in claim 12 wherein said feed channel includes a feed channel bore extending upwardly through said first sheet of polyimide and terminating in said top surface of said first sheet of polyimide, said sensor channel includes a sensor channel bore extending upwardly through said first sheet of polyimide and terminating in said top surface of said first sheet of polyimide proximate said feed channel bore, said valve means includes a flexible material positioned over said feed channel bore and said sensor channel bore, actuation means connected to said valve means for pressing said flexible material over said feed channel bore and said sensor channel bore to block communication therebetween and for relaxing said flexible material in spaced relation over said top surface of said first sheet of polyimide for opening communication therebetween.
Claim 16
Dependent Claim
17 words
A laminated microfluidic analyzer module as recited in claim 13 wherein said sensor is an optical sensor.
Claim 17
Dependent Claim
17 words
A laminated microfluidic analyzer module as recited in claim 13 wherein said sensor is an electrochemical sensor.
Claim 18
Dependent Claim
17 words
A laminated microfluidic analyzer module as recited in claim 15 wherein said electrochemical sensor includes an electrode.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-08-02 | 2003-02-01 | 2003-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-08-02 | 2007-02-01 | 2007-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-08-02 | 2011-02-01 | 2011-08-03 | $7700.00 | Window Closed / Lapsed |