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US4495203A
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Anhydrous composition, stable to oxidation, based on anthralin or one of its derivatives, in a carrier consisting of a fatty acid alkyl ester and a thickener, and its use in the treatment of skin diseases
Assignee: L'Oréal SA
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Filing: 1982-10-22
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Granted: 1985-01-22
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Expires: 2002-10-22
Abstract
Abstract Anhydrous composition, stable to oxidation, of anthralin or a derivative thereof. This composition contains anthralin or a derivative thereof in a carrier composed of (i) at least one fatty acid alkyl ester, the fatty acid having 12 to 18 carbon atoms and the alkyl radical having 2 or 3 carbon atoms, and (ii) at least one thickener taken from the group made up of silicas having particle sizes less than 30 m mu and polyethylene powders having densities between 0.9 and 0.96 (g/cm3). This composition is used in the treatment of skin diseases, particularly psoriasis.
Inventors
- 👤 Jean-Francois Grollier
- 👤 Georges Rosenbaum
- 👤 Josiane Allec
- 👤 Braham Shroot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 21:49
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K47/20; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/34; A61K8/347; A61Q; A61Q5/00; A61Q5/02
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
100 words
A stable to oxidation, anhydrous composition for treatment of diseases of the skin and particularly for psoriasis, containing 0.01 to 5% by weight of anthralin in a carrier comprising 60 to 99% by weight of a fatty acid alkyl ester, the fatty acid having from 12 to 18 carbon atoms and the alkyl radical having 2 to 3 carbon atoms, and 0.1 to 20% by weight of a thickener selected from the group consisting of silica having an average particle diameter of less than 30 mμ and ethylene polymer powder having a density of 0.9 to 0.96 (g/cm 3 ).
Claim 2
Dependent Claim
100 words
A stable to oxidation, anhydrous composition for treatment of diseases of the skin and particularly for psoriasis, containing 0.01 to 5% by weight of anthralin in a carrier comprising 60 to 99% by weight of a fatty acid alkyl ester, the fatty acid having from 12 to 18 carbon atoms and the alkyl radical having 2 to 3 carbon atoms, and 0.1 to 20% by weight of a thickener selected from the group consisting of silica having an average particle diameter of less than 30 mμ and ethylene polymer powder having a density of 0.9 to 0.96 (g/cm 3 ).
Claim 3
Dependent Claim
29 words
The composition of claim 1 wherein the fatty acid alkyl ester is selected from the group consisting of isopropyl laurate, isopropyl myristate, isopropyl palmitate, ethyl myristate and mixtures thereof.
Claim 4
Dependent Claim
18 words
The composition of claim 1 wherein anthralin is present at a concentration of 0.1 to 3% by weight.
Claim 5
Dependent Claim
20 words
The composition of claim 1 wherein the concentration of silica and/or polyethylene powder is from 2 to 15% by weight.
Claim 6
Dependent Claim
10 words
The composition of claim 1 which also contains salicyclic acid.
Claim 7
Dependent Claim
29 words
A process for the treatment of skin diseases, particularly for psoriasis, comprising applying to the skin lesions to be treated an effective amount of the compositions of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-22 | 1988-07-23 | 1989-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-22 | 1992-07-23 | 1993-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-22 | 1996-07-23 | 1997-01-22 | $7700.00 | Window Closed / Lapsed |