Tetrahydronaphthalene and indane derivatives

Abstract

Abstract The compounds of the formula ##STR1## wherein X and Y are independently --CH 2 -- or >C(CH 3 ) 2 ; Z is --CHR 8 --, >Co, >CR 8 OR 7 , --CHR 8 --CHR 8 --, --CHOR 7 --CH 2 --, --CO--CHOR 7 or --CHOR 7 --CHOR 7 --R 1 is a 5- or 6-membered, monocyclic heterocyclic group which optionally can be C-substituted by halogen, lower-alkyl, lower-alkoxy, acyloxy, nitro, hydroxy, amino, lower-alkylamino or di-lower-alkylamino and/or which can be substituted on a ring --NH-- group by lower-alkyl; R 2 and R 3 are independently hydrogen, lower-alkyl, trifluoromethyl or halogen and one of R 2 and R 3 always is trifluoromethyl or lower-alkyl; R 4 and R 5 are independently hydrogen, alkyl, alkoxy or halogen; R 6 is hydrogen, lower-alkyl or --OR 7 ; R 7 is hydrogen, lower-alkyl or acyl; R 8 is hydrogen or lower-alkyl; and R 7 and R 8 can be the same or different from one another. are useful for the treatment of neoplasms and dermatoses in mammals. The compounds can be manufactured from a corresponding bicyclic component and a heterocyclic component containing the residue R 1 by a Wittig, Horner or Grignard reaction and the optional subsequent transformation of reactive groups.

Inventors

• 👤 Michael Klaus
• 👤 Ekkehard Weiss

Bibliographic Details