US5296377A
Expired / Lapsed
US
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Control reagent containing a hydroxylamine or an antioxidant
Assignee: Roche Diabetes Care Inc
•
Filing: 1992-12-15
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Granted: 1994-03-22
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Expires: 2012-12-15
Abstract
Abstract Control reagents an oxidant or a hydroxylamine compound together with other ingredients, the most important of which is a known amount of the analyte for which the reagent acts as a control.
Inventors
- 👤 Myron Rapkin
- 👤 David Tabb
- 👤 Eric Diebold
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:16
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; C; C12; C12Q; C12Q1/00; C12Q1/54; C12Q1/60; G01N2496/00; G01N2496/80; G01N33/66; G01N33/92; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165; Y10T436/104998; Y10T436/106664; Y10T436/108331; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444; Y10T436/17
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
66 words
Control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of (i) a known amount of glucose or cholesterol; (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative, and (iii) a fluid carrier material.
Claim 2
Dependent Claim
66 words
Control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of (i) a known amount of glucose or cholesterol; (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative, and (iii) a fluid carrier material.
Claim 3
Dependent Claim
15 words
The control reagent of claim 1, wherein said additive is a hydroxylamine group containing compound.
Claim 4
Dependent Claim
36 words
The control reagent of claim 2, wherein said hydroxylamine group containing compound is selected from the group consisting of hydroxylamine, N-(tert-butyl) hydroxylamine, O-tert butyl hydroxylamine, O-benzyl hydroxylamine, N,O-dimethyl-hydroxylamine, N,N-dimethylhydroxylamine, N,N-dimethylhydroxylamine, N,N-diethyl hydroxylamine, and acid salts thereof.
Claim 5
Dependent Claim
11 words
The control reagent of claim 1, wherein said analyte is glucose.
Claim 6
Dependent Claim
11 words
The control reagent of claim 1, wherein said analyte is cholesterol.
Claim 7
Dependent Claim
13 words
The control reagent of claim 1, wherein said fluid carrier material is serum.
Claim 8
Dependent Claim
13 words
The control reagent of claim 1, wherein said fluid carrier material is plasma.
Claim 9
Dependent Claim
12 words
The control reagent of claim 1, wherein said carrier material is water.
Claim 10
Dependent Claim
14 words
The control reagent of claim 3, wherein said hydroxylamine control is N-tert butyl hydroxylamine.
Claim 11
Dependent Claim
14 words
The control reagent of claim 3, wherein said hydroxylamine group containing compound is N,N-dimethylhydroxylamine.
Claim 12
Dependent Claim
15 words
The control reagent of claim 1, wherein said control reagent also contains a viscosity agent.
Claim 13
Dependent Claim
14 words
The control reagent of claim 1, wherein said control reagent also contains a preservative.
Claim 14
Dependent Claim
14 words
The control reagent of claim 1, wherein said control reagent also contains a biocide.
Claim 15
Dependent Claim
14 words
The control reagent of claim 1, wherein said control reagent also contains a buffer.
Claim 16
Dependent Claim
12 words
The control reagent of claim 1, in the form of an emulsion.
Claim 17
Dependent Claim
32 words
The control reagent of claim 1, wherein said additive is (a) 2,6-ditertiarybutyl 4-methyl phenol; (b) 2-(1,1-dimethyl)-1,4-benzenedial; (c) 3,4,5-trihydroxylbenzoic acid; (d) vitamin E (e) a vitamin E or (f) a vitamin E derivative.
Claim 18
Dependent Claim
62 words
Lyophilized control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of: (i) a known amount of glucose or cholesterol; and (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative.
Claim 19
Dependent Claim
62 words
Lyophilized control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of: (i) a known amount of glucose or cholesterol; and (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative.
References Cited (Backward Citations)
US3260648A
Cited
US3274062A
Cited
US3466249A
Cited
US3852415A
Cited
US3920400A
Cited
US3859047A
Cited
US3920580A
Cited
US4078892A
Cited
US4054488A
Cited
US4123384A
Cited
US3973913A
Cited
US4372874A
Cited
US4127502A
Cited
US4121905A
Cited
US4126575A
Cited
US4230601A
Cited
US4276376A
Cited
US4193766A
Cited
US4199471A
Cited
US4298498A
Cited
US4301028A
Cited
US4260579A
Cited
US4529704A
Cited
US4405718A
Cited
US4438202A
Cited
US4554249A
Cited
US4839279A
Cited
US4643976A
Cited
US4678754A
Cited
US4729959A
Cited
US5028542A
Cited
US5149321A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-21 | 1997-09-20 | 1998-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-21 | 2001-09-20 | 2002-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-21 | 2005-09-20 | 2006-03-22 | $7700.00 | Window Closed / Lapsed |