Patent US5296377A successfully refreshed from Google Patents.
US5296377A
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Control reagent containing a hydroxylamine or an antioxidant
Assignee: Roche Diabetes Care Inc
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Filing: 1992-12-15
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Granted: 1994-03-22
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Expires: 2012-12-15
Abstract
Abstract Control reagents an oxidant or a hydroxylamine compound together with other ingredients, the most important of which is a known amount of the analyte for which the reagent acts as a control.
Inventors
- 👤 Myron Rapkin
- 👤 David Tabb
- 👤 Eric Diebold
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 10:21
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; C; C12; C12Q; C12Q1/00; C12Q1/54; C12Q1/60; G01N2496/00; G01N2496/80; G01N33/66; G01N33/92; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165; Y10T436/104998; Y10T436/106664; Y10T436/108331; Y10T436/14; Y10T436/142222; Y10T436/143333; Y10T436/144444; Y10T436/17
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
66 words
Control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of (i) a known amount of glucose or cholesterol; (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative, and (iii) a fluid carrier material.
Claim 2
Dependent Claim
66 words
Control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of (i) a known amount of glucose or cholesterol; (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative, and (iii) a fluid carrier material.
Claim 3
Dependent Claim
15 words
The control reagent of claim 1, wherein said additive is a hydroxylamine group containing compound.
Claim 4
Dependent Claim
36 words
The control reagent of claim 2, wherein said hydroxylamine group containing compound is selected from the group consisting of hydroxylamine, N-(tert-butyl) hydroxylamine, O-tert butyl hydroxylamine, O-benzyl hydroxylamine, N,O-dimethyl-hydroxylamine, N,N-dimethylhydroxylamine, N,N-dimethylhydroxylamine, N,N-diethyl hydroxylamine, and acid salts thereof.
Claim 5
Dependent Claim
11 words
The control reagent of claim 1, wherein said analyte is glucose.
Claim 6
Dependent Claim
11 words
The control reagent of claim 1, wherein said analyte is cholesterol.
Claim 7
Dependent Claim
13 words
The control reagent of claim 1, wherein said fluid carrier material is serum.
Claim 8
Dependent Claim
13 words
The control reagent of claim 1, wherein said fluid carrier material is plasma.
Claim 9
Dependent Claim
12 words
The control reagent of claim 1, wherein said carrier material is water.
Claim 10
Dependent Claim
14 words
The control reagent of claim 3, wherein said hydroxylamine control is N-tert butyl hydroxylamine.
Claim 11
Dependent Claim
14 words
The control reagent of claim 3, wherein said hydroxylamine group containing compound is N,N-dimethylhydroxylamine.
Claim 12
Dependent Claim
15 words
The control reagent of claim 1, wherein said control reagent also contains a viscosity agent.
Claim 13
Dependent Claim
14 words
The control reagent of claim 1, wherein said control reagent also contains a preservative.
Claim 14
Dependent Claim
14 words
The control reagent of claim 1, wherein said control reagent also contains a biocide.
Claim 15
Dependent Claim
14 words
The control reagent of claim 1, wherein said control reagent also contains a buffer.
Claim 16
Dependent Claim
12 words
The control reagent of claim 1, in the form of an emulsion.
Claim 17
Dependent Claim
32 words
The control reagent of claim 1, wherein said additive is (a) 2,6-ditertiarybutyl 4-methyl phenol; (b) 2-(1,1-dimethyl)-1,4-benzenedial; (c) 3,4,5-trihydroxylbenzoic acid; (d) vitamin E (e) a vitamin E or (f) a vitamin E derivative.
Claim 18
Dependent Claim
62 words
Lyophilized control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of: (i) a known amount of glucose or cholesterol; and (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative.
Claim 19
Dependent Claim
62 words
Lyophilized control reagent useful in determining an analyte selected from the group consisting of glucose and cholesterol, consisting essentially of: (i) a known amount of glucose or cholesterol; and (ii) an additive selected from the group consisting of (a) a hydroxylamine group containing compound; (b) 2,6-ditertiarybutyl 4-methyl phenol; (c) 2-(1,1-dimethyl)-1,4-benzenedial; (d) 3,4,5-trihydroxylbenzoic acid; (e) vitamin E and (f) a vitamin E derivative.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-21 | 1997-09-20 | 1998-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-21 | 2001-09-20 | 2002-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-21 | 2005-09-20 | 2006-03-22 | $7700.00 | Window Closed / Lapsed |